journal article·2021-09-29

Biocompatible Ruthenium Single-Atom Catalyst for Cascade Enzyme-Mimicking Therapy

Wenyu Wang, Yang Zhu, Xiaorong Zhu, Yafei Zhao, Zhenggang Xue, Can Xiong, Zhiyuan Wang, Yunteng Qu, Junjie Cheng, Min Chen, Manman Liu, Fangyao Zhou, Haoran Zhang, Zheng Jiang, Yidong Hu, Huang Zhou, Huijuan Wang, Yafei Li, Yangzhong Liu, Yuen Wu

ACS Applied Materials & Interfaces· Volume 13· Issue 38
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Abstract

Rationally constructing single-atom enzymes (SAEs) with superior activity, robust stability, and good biocompatibility is crucial for tumor therapy but still remains a substantial challenge. In this work, we adopt biocompatible carbon dots as the carrier material to load Ru single atoms, achieving Ru SAEs with superior multiple enzyme-like activity and stability. Ru SAEs behave as oxidase, peroxidase, and glutathione oxidase mimics to synchronously catalyze the generation of reactive oxygen species (ROS) and the depletion of glutathione, thus amplifying the ROS damage and finally causing the death of cancer cells. Notably, Ru SAEs exhibit excellent peroxidase-like activity with a specific activity of 7.5 U/mg, which surpasses most of the reported SAEs and is 20 times higher than that of Ru/C. Theoretical results reveal that the electrons of the Ru 4d orbital in Ru SAEs are transferred to O atoms in H2O2 and then efficiently activate H2O2 to produce •OH. Our work may provide some inspiration for the design of SAEs for cancer therapy.
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Research context

OpenAlex topics: Advanced Nanomaterials in Catalysis · Carbon and Quantum Dots Applications · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), University of Science and Technology of China, Hefei 230026, China

CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei 230026, China

Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China

Shanghai Synchrotron Radiation Facilities, Shanghai Institute of Applied Physics, Chinese Academy of Science, Shanghai 201800, China

Experimental Center of Engineering and Material Science, University of Science and Technology of China, Hefei 230026, China

Dalian National Laboratory for Clean Energy, Dalian 116023, China

Funding

Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Chinese Academy of Sciences

References (49)

Show source-provided references
1. 10.1038/nrg129710.1038/nrg1297 ↗
2. 10.1038/nm.293310.1038/nm.2933 ↗
3. 10.1038/s41596-018-0001-110.1038/s41596-018-0001-1 ↗
4. 10.1021/acs.chemrev.8b0067210.1021/acs.chemrev.8b00672 ↗
5. 10.1126/sciadv.abc873310.1126/sciadv.abc8733 ↗
6. 10.1038/nnano.2007.26010.1038/nnano.2007.260 ↗
7. 10.1002/adma.20190788010.1002/adma.201907880 ↗
8. 10.1038/s41467-018-05798-x10.1038/s41467-018-05798-x ↗
9. 10.1021/jacs.9b1287310.1021/jacs.9b12873 ↗
10. 10.1021/acsami.0c0103910.1021/acsami.0c01039 ↗
11. 10.1002/anie.20191177010.1002/anie.201911770 ↗
12. 10.1038/s41467-017-00424-810.1038/s41467-017-00424-8 ↗
13. 10.1002/adma.20190527110.1002/adma.201905271 ↗
14. 10.1002/anie.20200511110.1002/anie.202005111 ↗
15. 10.1002/adfm.20170060510.1002/adfm.201700605 ↗
16. 10.1021/jacs.8b1185610.1021/jacs.8b11856 ↗
17. 10.1038/s41467-019-14199-710.1038/s41467-019-14199-7 ↗
18. 10.1038/s41565-020-0665-x10.1038/s41565-020-0665-x ↗
19. 10.1038/s41560-017-0078-810.1038/s41560-017-0078-8 ↗
20. 10.1002/anie.20190564510.1002/anie.201905645 ↗
21. 10.1002/anie.20191218210.1002/anie.201912182 ↗
22. 10.1002/anie.20201715210.1002/anie.202017152 ↗
23. 10.1002/anie.20200886810.1002/anie.202008868 ↗
24. 10.1126/sciadv.aav549010.1126/sciadv.aav5490 ↗
25. 10.1021/acsnano.9b0045710.1021/acsnano.9b00457 ↗
26. 10.1038/s41929-021-00609-x10.1038/s41929-021-00609-x ↗
27. 10.1038/s41565-019-0373-610.1038/s41565-019-0373-6 ↗
28. 10.1038/s41551-020-0540-y10.1038/s41551-020-0540-y ↗
29. 10.1002/anie.20171246910.1002/anie.201712469 ↗
30. 10.1002/anie.20201710210.1002/anie.202017102 ↗
31. 10.1039/c4cs00269e10.1039/c4cs00269e ↗
32. 10.1021/jacs.9b0318210.1021/jacs.9b03182 ↗
33. 10.1002/anie.20201439710.1002/anie.202014397 ↗
34. 10.1002/sstr.20200005110.1002/sstr.202000051 ↗
35. 10.1021/acscatal.7b0342310.1021/acscatal.7b03423 ↗
36. 10.1021/acs.jpca.0c0137510.1021/acs.jpca.0c01375 ↗
37. 10.1103/physrevb.50.1795310.1103/physrevb.50.17953 ↗
38. 10.1103/physrevlett.77.386510.1103/physrevlett.77.3865 ↗
39. 10.1063/1.132967210.1063/1.1329672 ↗
40. 10.1021/jp064341w10.1021/jp064341w ↗
41. 10.1021/acsnano.9b0045210.1021/acsnano.9b00452 ↗
42. 10.1002/smll.20200234310.1002/smll.202002343 ↗
43. 10.1063/1.11778910.1063/1.117789 ↗
44. 10.1038/s41557-018-0100-110.1038/s41557-018-0100-1 ↗
45. 10.1021/jacs.7b1038510.1021/jacs.7b10385 ↗
46. 10.1002/adma.20190449610.1002/adma.201904496 ↗
47. 10.1002/adma.20200323810.1002/adma.202003238 ↗
48. 10.1002/adma.20200243910.1002/adma.202002439 ↗
49. 10.1002/anie.20140847610.1002/anie.201408476 ↗