Efficient Iron and ROS Nanoscavengers for Brain Protection after Intracerebral Hemorrhage
Source abstract
Abstract
Intracerebral hemorrhage (ICH) will be accompanied by the overload of iron and reactive oxygen species (ROS) following hematoma clearance. Although deferoxamine (DFO) has been widely utilized as a clinical first-line siderophore to remove the iron overload, the ROS-inducing damage still greatly limits the therapeutic effect of DFO. To address this issue, we designed and fabricated a series of dual-functional macromolecular nanoscavengers featuring high-density DFO units and catechol moieties. Note that the former units could effectively remove the iron overload, while the latter ones could efficiently deplete the ROS. The resulting nanoscavengers efficiently down-regulate the iron and ROS levels as well as significantly reduce the cell death in both iron-overloaded RAW 264.7 cells and the ICH mice model. This work suggests a novel clue for the ICH-ameliorated iron-depleting interventional therapeutic regimen.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Intracerebral and Subarachnoid Hemorrhage Research · Alzheimer's disease research and treatments · Dendrimers and Hyperbranched Polymers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China
Neurosurgery Research Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China
Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Peking Union Medical College, Chengdu, Sichuan 610052, P. R. China
Core Facilities of West China Hospital, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China
Funding
National Natural Science Foundation of China · 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University
References (51)
Show source-provided references
1. 10.1021/jacs.9b1075510.1021/jacs.9b10755 ↗
2. 10.1073/pnas.181938211610.1073/pnas.1819382116 ↗
3. 10.1038/nchembio.107110.1038/nchembio.1071 ↗
4. 10.1038/nrd.2016.24810.1038/nrd.2016.248 ↗
5. 10.1021/acs.nanolett.8b0242810.1021/acs.nanolett.8b02428 ↗
6. 10.1038/s41467-019-13143-z10.1038/s41467-019-13143-z ↗
7. 10.1016/j.biomaterials.2018.09.04010.1016/j.biomaterials.2018.09.040 ↗
8. 10.1021/acsnano.7b0817210.1021/acsnano.7b08172 ↗
9. 10.1016/j.jconrel.2018.05.01110.1016/j.jconrel.2018.05.011 ↗
10. 10.1016/j.tips.2017.04.00510.1016/j.tips.2017.04.005 ↗
11. 10.1021/bc00033a00310.1021/bc00033a003 ↗
12. 10.1073/pnas.141344511210.1073/pnas.1413445112 ↗
13. 10.1016/j.jconrel.2019.07.00910.1016/j.jconrel.2019.07.009 ↗
14. 10.7150/thno.3184710.7150/thno.31847 ↗
15. 10.1002/anie.20100004410.1002/anie.201000044 ↗
16. 10.1002/smll.20190704210.1002/smll.201907042 ↗
17. 10.1002/admi.20200063210.1002/admi.202000632 ↗
18. 10.1016/j.giant.2020.10002210.1016/j.giant.2020.100022 ↗
19. 10.1039/c9mh01197h10.1039/c9mh01197h ↗
20. 10.1039/d0mh01317j10.1039/d0mh01317j ↗
21. 10.1039/d0bm01070g10.1039/d0bm01070g ↗
22. 10.1016/j.progpolymsci.2018.08.00510.1016/j.progpolymsci.2018.08.005 ↗
23. 10.1016/j.progpolymsci.2012.06.00410.1016/j.progpolymsci.2012.06.004 ↗
24. 10.1021/acsnano.9b0552110.1021/acsnano.9b05521 ↗
25. 10.1038/nchem.179310.1038/nchem.1793 ↗
26. 10.1021/ja203077x10.1021/ja203077x ↗
27. 10.1002/anie.20180480210.1002/anie.201804802 ↗
28. 10.31635/ccschem.020.20190008410.31635/ccschem.020.201900084 ↗
29. 10.31635/ccschem.020.20190007710.31635/ccschem.020.201900077 ↗
30. 10.1002/adfm.20180212710.1002/adfm.201802127 ↗
31. 10.1002/marc.20170044610.1002/marc.201700446 ↗
32. 10.1021/jacs.6b1101310.1021/jacs.6b11013 ↗
33. 10.1007/s10118-020-2486-710.1007/s10118-020-2486-7 ↗
34. 10.1039/d0tb00578a10.1039/d0tb00578a ↗
35. 10.1093/oxfordjournals.jbchem.a12211610.1093/oxfordjournals.jbchem.a122116 ↗
36. 10.1021/nn403507410.1021/nn4035074 ↗
37. 10.1016/j.biomaterials.2008.09.05710.1016/j.biomaterials.2008.09.057 ↗
38. 10.1002/mabi.20160024410.1002/mabi.201600244 ↗
39. 10.1021/acsnano.8b0352510.1021/acsnano.8b03525 ↗
40. 10.1016/s0010-8545(02)00050-410.1016/s0010-8545(02)00050-4 ↗
41. 10.1002/adma.20170487710.1002/adma.201704877 ↗
42. 10.1038/nprot.2007.51310.1038/nprot.2007.513 ↗
43. 10.1161/strokeaha.109.56983010.1161/strokeaha.109.569830 ↗
44. 10.1073/pnas.86.24.1010810.1073/pnas.86.24.10108 ↗
45. 10.1016/j.jconrel.2015.01.02510.1016/j.jconrel.2015.01.025 ↗
46. 10.1021/acsami.6b0907710.1021/acsami.6b09077 ↗
47. 10.1002/adhm.20170016210.1002/adhm.201700162 ↗
48. 10.1021/acscentsci.9b0028410.1021/acscentsci.9b00284 ↗
49. 10.1021/acsnano.8b0882310.1021/acsnano.8b08823 ↗
50. 10.1016/j.jconrel.2018.05.02510.1016/j.jconrel.2018.05.025 ↗
51. 10.1016/j.biomaterials.2016.06.01910.1016/j.biomaterials.2016.06.019 ↗