journal article·2022-07-06

Zn2+ Cross-Linked Alginate Carrying Hollow Silica Nanoparticles Loaded with RL-QN15 Peptides Provides Promising Treatment for Chronic Skin Wounds

Pan Qin, Jing Tang, Dandan Sun, Ying Yang, Naixin Liu, Yilin Li, Zhe Fu, Yinglei Wang, Chao Li, Xiaojie Li, Yue Zhang, Yixiang Liu, Siyu Wang, Jun Sun, Ziwei Deng, Li He, Ying Wang, Xinwang Yang

ACS Applied Materials & Interfaces· Volume 14· Issue 26
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Abstract

Chronic and non-healing wounds pose a great challenge to clinical management and patients. Many studies have explored novel interventions against skin wounds, with bioactive peptides, nanoparticles, and hydrogels arousing considerable attention regarding their therapeutic potential. In this study, the prohealing peptide RL-QN15 was loaded into hollow silica nanoparticles (HSNs), with these HSN@RL-QN15 nanocomposites then combined with zinc alginate (ZA) gels to obtain HSN@RL-QN15/ZA hydrogel. The characteristics, biological properties, and safety profiles of the hydrogel composites were then evaluated. Results showed that the hydrogel had good porosity, hemocompatibility, biocompatibility, and broad-spectrum antimicrobial activity, with the slow release of loaded RL-QN15. Further analysis indicated that the hydrogel promoted skin cell proliferation and keratinocyte scratch repair, regulated angiogenesis, reduced inflammation, and accelerated re-epithelialization and granulation tissue formation, resulting in the rapid healing of both full-thickness skin wounds and methicillin-resistant Staphylococcus aureus biofilm-infected chronic wounds in mice. This peptide-based hydrogel provides a novel intervention for the treatment of chronic skin wounds and shows promise as a wound dressing in the field of tissue regeneration.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Wound Healing and Treatments · Antimicrobial Peptides and Activities · Silk-based biomaterials and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biochemistry and Molecular Biology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China

Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China

Department of Endocrinology, Affiliated Hospital of Yunnan University, Kunming, Yunnan 650021, China

Key Laboratory of Applied Surface and Colloid Chemistry, National Ministry of Education, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi’an, Shaanxi 710119, China

Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650500, China

Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, Yunnan 650504, China

Funding

Ministry of Education of the People's Republic of China · Yunnan University · Central University Basic Research Fund of China · National Natural Science Foundation of China · Kunming Medical University Union Foundation · Natural Science Basic Research Plan in Shaanxi Province of China · Yunnan Applied Basic Research Project Foundation · Innovation Capability Support Program of Shaanxi · Science and Technology Leadership Talent Project in Yunnan China

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