journal article·2020-02-19

Highly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter

Jian Du, Shunjie Liu, Pengfei Zhang, Haixiang Liu, Yuanyuan Li, Wei He, Chunbin Li, Joe H. C. Chau, Ryan T. K. Kwok, Jacky W. Y. Lam, Lintao Cai, Yuhua Huang, Weijie Zhang, Jianquan Hou, Ben Zhong Tang

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Abstract

Iatrogenic ureteral injury is a dreaded complication of abdominal and pelvic surgeries, and thus, intraoperative identification of ureters is of paramount importance but lacks efficient methods and probes. Herein, we used near-infrared II (NIR-II, 1000-1700 nm) fluorescence imaging with advantages of higher spatial resolution, deeper tissue penetration, lower light scattering, and less tissue autofluorescence to identify ureters by aggregation-induced emission luminogen dots (AIE dots). The intraoperative ureteral injuries and common ureteral diseases can be visualized timely and precisely. Due to the longer emission wavelength and higher quantum yield of the AIE dots, it largely outperforms the commercial indocyanine green dye in brightness and penetration depth. It was the first time to realize the intraoperative identification of ureters in vivo using NIR-II imaging. Thus, our work provides a new platform for intraoperative monitoring during clinical operation.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Ureteral procedures and complications · Nanoplatforms for cancer theranostics · Luminescence Properties of Advanced Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Urology, The First Affiliated Hospital of Soochow University, NO. 188 Shizi Road, Suzhou 215006, China

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science and State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials, Department Chemical and Biological Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong, China

Guangdong Key Laboratory of Nanomedicine, Shenzhen, engineering Laboratory of nanomedicine and nanoformulations, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

HKUST Shenzhen Research Institute, No. 9 Yuexing First Road, South Area Hi-tech Park, Nanshan, Shenzhen 518057, China

Center for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China

Funding

Research Grants Council, University Grants Committee · Natural Science Foundation of Jiangsu Province · Shenzhen Science and Technology Innovation Commission · Innovation and Technology Commission · National Natural Science Foundation of China · Jiangsu Provincial Key Medical Discipline · Science and Technology Project for the Youth of Suzhou · Ming Wai Lau Centre for Reparative Medicine Associate Member Programme

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