DataVXACS Applied Materials & InterfacesPaper
journal article·2021-10-06

A Co-Doped Fe3O4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke

Yunsheng Liu, Xiaojun Wang, Xiangzhu Li, Shanshan Qiao, Guodong Huang, Dirk Matthias Hermann, Thorsten Roland Doeppner, Muling Zeng, Wei Liu, Gelin Xu, Lijie Ren, Yuan Zhang, Wenlan Liu, Eudald Casals, Weiping Li, Ya-Chao Wang

ACS Applied Materials & Interfaces· Volume 13· Issue 39
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Source abstract

Abstract

Acute ischemic stroke has become the major cause of mortality and disability worldwide. Following ischemic stroke, the reperfusion injury is mainly mediated by the burst of reactive oxygen and nitrogen species (RONS). Therefore, blocking the excessive production or removing RONS holds great promise as a potential therapeutic strategy. Herein, we developed a Co-doped Fe3O4 nanozyme that is capable of scavenging H2O2, O2•-, •NO, and ONOO- in vitro and in vivo and provides neuroprotection against ischemic stroke. In vitro experiments showed that pre-incubation with the Co-Fe3O4 nanozyme could prevent neurotoxicity and neuroinflammation induced by H2O2 or lipopolysaccharide, respectively, in HT22 cells. After intravenous administration, the Co-Fe3O4 nanozyme showed no signs of toxicity in peripheral organs of C57BL/6J mice, even after prolonged delivery for 4 weeks. In permanent photothrombotic stroke model and transient middle cerebral artery occlusion stroke model, the Co-Fe3O4 nanozyme specifically accumulated in the infarct rim at 72 h post-stroke and was endocytosed by neurons, astrocytes, microglia, and endothelial cells. Importantly, the Co-Fe3O4 nanozyme delivery reduced the infarct volume in both stroke models. The observation that the Co-Fe3O4 nanozyme was efficacious in two well-characterized ischemic stroke models provides strong evidence that it represents a powerful tool for targeting oxidative and nitrosative stress in the ischemic brain.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

Nanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Electrochemical sensors and biosensors · Neuroinflammation and Neurodegeneration Mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China

Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

The Central Laboratory of Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China

Department of Neurology, University of Hospital Essen, Essen 45147, Germany

Department of Neurology, University of Göttingen Medical School, Göttingen 37075, Germany

School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China

School of Electronic and Information Engineering, Harbin Institute of Technology, Shenzhen, Guangdong 518055, China

Department of Neurology, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China

The Institute Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518035, China

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Guangdong Innovation Platform of Translational Research for Cerebrovascular Diseases · Basic research projects of Shenzhen Science and Technology Program

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