DataVXACS Applied Materials & InterfacesPaper
journal article·2023-01-11Open access

Acceleration of Oral Wound Healing under Diabetes Mellitus Conditions Using Bioadhesive Hydrogel

Jiwei Sun, Tiantian Chen, Baoying Zhao, Wenjie Fan, Yufeng Shen, Haojie Wei, Man Zhang, Wenhao Zheng, Jinfeng Peng, Jinyu Wang, Yifan Wang, Lihong Fan, Yingying Chu, Lili Chen, Cheng Yang

ACS Applied Materials & Interfaces· Volume 15· Issue 1
Publisher pageOpen full text
Source abstract

Abstract

Oral wounds under diabetic conditions display a significant delay during the healing process, mainly due to oxidative stress-induced inflammatory status and abnormal immune responses. Besides, the wet and complicated dynamic environment of the oral cavity impedes stable treatment of oral wounds. To overcome these, a biomimetic hydrogel adhesive was innovatively developed based on a mussel-inspired multifunctional structure. The adhesive displays efficient adhesion and mechanical harmony on the oral mucosa through enhanced bonding in an acidic proinflammatory environment. The bioadhesive hydrogel exhibits excellent antioxidative properties by mimicking antioxidative enzymatic activities to reverse reactive oxygen species (ROS)-mediated immune disorders. Experiments on oral wounds of diabetic rats showed that this hydrogel adhesive could effectively protect against mucosal wounds and obviously shorten the inflammatory phase, thus promoting the wound-healing process. Therefore, this study offers a promising therapeutic choice with the potential to advance the clinical treatment of diabetic oral wounds.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Wound Healing and Treatments · Diabetic Foot Ulcer Assessment and Management · Oral microbiology and periodontitis research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan430022, China

School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430030, China

Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan430022, China

School of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan430070, China

School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan430070, China

Funding

Ministry of Science and Technology of the People's Republic of China · Department of Science and Technology, Hubei Provincial People's Government · Key Laboratory of Oral Frontal Development and Regeneration, Huazhong University of Science and Technology

References (44)

Show source-provided references
1. 10.1038/s41467-019-08923-610.1038/s41467-019-08923-6 ↗
2. Petersen P. E. · Bull. W. H. O. · 2005 · 83 · 661
3. 10.1016/j.trsl.2021.06.00310.1016/j.trsl.2021.06.003 ↗
4. 10.1160/TH03-07-044610.1160/TH03-07-0446 ↗
5. 10.1111/jcpe.1220610.1111/jcpe.12206 ↗
6. 10.1016/j.archoralbio.2014.10.00810.1016/j.archoralbio.2014.10.008 ↗
7. 10.1016/j.lfs.2016.04.03310.1016/j.lfs.2016.04.033 ↗
8. 10.1111/j.1365-2133.2008.08789.x10.1111/j.1365-2133.2008.08789.x ↗
9. 10.1038/414813a10.1038/414813a ↗
10. 10.1016/j.redox.2018.09.02510.1016/j.redox.2018.09.025 ↗
11. 10.1111/edt.1237210.1111/edt.12372 ↗
12. 10.1155/2020/371470410.1155/2020/3714704 ↗
13. 10.1039/c0mb00317d10.1039/c0mb00317d ↗
14. 10.1002/stem.242910.1002/stem.2429 ↗
15. 10.3390/polym1209216810.3390/polym12092168 ↗
16. 10.1097/01.ASW.0000513089.75457.2210.1097/01.ASW.0000513089.75457.22 ↗
17. 10.1021/acsami.7b1668010.1021/acsami.7b16680 ↗
18. 10.1097/01.sap.0000198731.12407.0c10.1097/01.sap.0000198731.12407.0c ↗
19. 10.1016/S0002-9440(10)63754-610.1016/S0002-9440(10)63754-6 ↗
20. 10.1002/adhm.20190150210.1002/adhm.201901502 ↗
21. 10.1038/s41579-018-0089-x10.1038/s41579-018-0089-x ↗
22. 10.1016/j.addr.2011.02.00810.1016/j.addr.2011.02.008 ↗
23. 10.1007/s00464-007-9243-710.1007/s00464-007-9243-7 ↗
24. 10.1038/s41586-019-1710-510.1038/s41586-019-1710-5 ↗
25. 10.1126/scitranslmed.aba801410.1126/scitranslmed.aba8014 ↗
26. 10.1016/j.ijbiomac.2021.12.00710.1016/j.ijbiomac.2021.12.007 ↗
27. 10.1021/acsami.8b1664510.1021/acsami.8b16645 ↗
28. 10.1002/term.265610.1002/term.2656 ↗
29. 10.1038/s41392-021-00830-x10.1038/s41392-021-00830-x ↗
30. 10.1002/adma.20210566710.1002/adma.202105667 ↗
31. 10.1002/adhm.20210180810.1002/adhm.202101808 ↗
32. 10.1021/acsami.2c0887010.1021/acsami.2c08870 ↗
33. 10.1016/j.jdiacomp.2015.12.01710.1016/j.jdiacomp.2015.12.017 ↗
34. Latta M. A. · J. Adhes. Dent. · 2020 · 22 · 99
35. 10.1039/D0MH01231A10.1039/D0MH01231A ↗
36. 10.1016/j.biomaterials.2012.07.05510.1016/j.biomaterials.2012.07.055 ↗
37. 10.1038/s41467-021-21989-510.1038/s41467-021-21989-5 ↗
38. 10.4012/dmj.2011-11010.4012/dmj.2011-110 ↗
39. 10.1155/2021/885275910.1155/2021/8852759 ↗
40. 10.1021/jf503819t10.1021/jf503819t ↗
41. 10.1038/s41467-020-18276-010.1038/s41467-020-18276-0 ↗
42. 10.1016/j.biopha.2020.10984710.1016/j.biopha.2020.109847 ↗
43. 10.1016/j.redox.2021.10213410.1016/j.redox.2021.102134 ↗
44. 10.1016/j.msec.2021.11238510.1016/j.msec.2021.112385 ↗