journal article·2018-11-14

Heterostructured Silk-Nanofiber-Reduced Graphene Oxide Composite Scaffold for SH-SY5Y Cell Alignment and Differentiation

Huaibin Qing, Guorui Jin, Guoxu Zhao, Guoyou Huang, Yufei Ma, Xiaohui Zhang, Baoyong Sha, Zhengtang Luo, Tian Jian Lu, Feng Xu

ACS Applied Materials & Interfaces· Volume 10· Issue 45
Publisher page

Abstract

Stem cell therapy is promising for treating traumatic injuries of the central nervous system, where a major challenge is to effectively differentiate neural stem cells into neurons with uniaxial alignment. Recently, controlling stem cell fate by modulating biophysical cues (e.g., stiffness, conductivity, and patterns) has emerged as an attractive approach. Herein, we report a new heterostructure composite scaffold to induce cell-oriented growth and enhance the neuronal differentiation of SH-SY5Y cells. The scaffold is composed of aligned electrospinning silk nanofibers coated on reduced graphene paper with high conductivity and good biocompatibility. Our experimental results demonstrate that the composite scaffold can effectively induce the oriented growth and enhance neuronal differentiation of SH-SY5Y cells. Our study develops a novel scaffold for enhancing the differentiation of SH-SY5Y cells into neurons, which holds great potential in the treatment of neurological diseases and injuries.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Graphene and Nanomaterials Applications · Silk-based biomaterials and applications · Nerve injury and regeneration

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, P.R. China

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, P.R. China

State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R. China

Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an 710049, P.R. China

Institute of Basic Medical Science, School of Basic Medical Science, Xi’an Medical University, Xi’an 710021, China

Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong

MOE Key Laboratory for Multifunctional Materials and Structures, Xi’an Jiaotong University, Xi’an 710049, P.R. China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Shaanxi Province · National Project Cultivating Foundation of Xi?an Medical University

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