journal article·2021-08-11

Cancer Cytomembrane-Cloaked Prussian Blue Nanoparticles Enhance the Efficacy of Mild-Temperature Photothermal Therapy by Disrupting Mitochondrial Functions of Cancer Cells

Pei Wang, Ranjith Kumar Kankala, Biaoqi Chen, Yang Zhang, Mingzhi Zhu, Xuemei Li, Ruimin Long, Dayun Yang, Rumen Krastev, Shibin Wang, Xin Xiong, Yuangang Liu

ACS Applied Materials & Interfaces· Volume 13· Issue 31
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Abstract

Despite its success against cancer, photothermal therapy (PTT) (>50 °C) suffers from several limitations such as triggering inflammation and facilitating immune escape and metastasis and also damage to the surrounding normal cells. Mild-temperature PTT has been proposed to override these shortcomings. We developed a nanosystem using HepG2 cancer cell membrane-cloaked zinc glutamate-modified Prussian blue nanoparticles with triphenylphosphine-conjugated lonidamine (HmPGTL NPs). This innovative approach achieved an efficient mild-temperature PTT effect by downregulating the production of intracellular ATP. This disrupts a section of heat shock proteins that cushion cancer cells against heat. The physicochemical properties, anti-tumor efficacy, and mechanisms of HmPGTL NPs both in vitro and in vivo were investigated. Moreover, the nanoparticles cloaked with the HepG2 cell membrane substantially prolonged the circulation time in vivo. Overall, the designed nanocomposites enhance the efficacy of mild-temperature PTT by disrupting the production of ATP in cancer cells. Thus, we anticipate that the mild-temperature PTT nanosystem will certainly present its enormous potential in various biomedical applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China

Jiangxi Key Laboratory of Stomatology and Biomedicine, School of Stomatology, Nanchang University, Nanchang 330006, P. R. China

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361021, P. R. China

Institute for Translational Medicine, School of Basic Medical Science, Fujian Medical University, Fuzhou 350122, P. R. China

Faculty for Applied Chemistry, Reutlingen University, Alteburgstr, 150, Reutlingen 72762, Germany

NMI Natural and Medical Sciences Institute, University of Tübingen, Markwiesenstr, 55, Reutlingen 72770, Germany

Funding

Natural Science Foundation of Fujian Province · National Natural Science Foundation of China · Open Project of Key Laboratory of Cancer and Neurodegenerative Disease Transformation in Fujian Province · National Marine Economic Innovation and Development Project · Subsidized Project for Postgraduatesâ?? Innovative Fund in Scientific Research of Huaqiao University · Program for Innovative Research Team in Science and Technology in Fujian Province University · the Science Research Foundation of National Health and Family Planning Commission of PRC & United Fujian Provincial Health and Education Project for Tacking the Key Research

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