DataVXACS Applied Materials & InterfacesPaper
journal article·2019-05-08

Facial Control Intramolecular Charge Transfer of Quinoid Conjugated Polymers for Efficient in Vivo NIR-II Imaging

Wansu Zhang, Ting Huang, Jiewei Li, Pengfei Sun, Yufeng Wang, Wei Shi, Wei Han, Wenjun Wang, Quli Fan, Wei Huang

ACS Applied Materials & Interfaces· Volume 11· Issue 18
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Source abstract

Abstract

Low-band gap conjugated polymers with donor-acceptor (D-A) structures have emerged as second near-infrared (NIR-II) fluorescence probes for biological imaging. However, how to control the intramolecular charge transfer (ICT) to maintain the low band gap and improve the NIR-II fluorescence intensity is an urgent issue. Here, the quinoid polymers have been developed to effectively regulate the ICT for brighter NIR-II fluorescence signals. Thiophene repeat chain units of different lengths (T, 2T, and 3T) were utilized to link with electron-withdrawing ester-substituted thieno[3,4- b]thiophene (TT) to alter the density of the electron-withdrawing side groups for controlling the ICT. By increasing the thiophene chain length from TT-T to TT-3T, the density of the electron-withdrawing groups decreased and the ICT was weakened. In the case of NIR absorption and NIR-II emission, weakened ICT leads to brighter NIR-II fluorescence. After the preparation of the water-soluble quinoid polymer probes (CPs), TT-3T CPs with weak ICT exhibited the brightest NIR-II fluorescent signals among the three quinoid polymer probes. Several NIR-II biomedical imaging applications, including in vivo cell tracking, blood vascular system images, and lymphatic drainage mapping, show that the TT-3T CP-based nanoprobe had excellent characteristics of long-term stability and high NIR-II spatial resolutions in vivo.
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Research context

PolymersNanomaterials

OpenAlex topics: Luminescence and Fluorescent Materials · Conducting polymers and applications · Optical Imaging and Spectroscopy Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing, Jiangsu 210093, P. R. China

Key Lab of Optical Communication Science and Technology of Shandong Province & School of Physics Science and Information Engineering, Liaocheng University, Liaocheng 252059, China

Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi’an 710072, Shaanxi, China

Funding

National Natural Science Foundation of China · Nanjing University of Posts and Telecommunications · Ministry of Science and Technology of the People's Republic of China · Government of Jiangsu Province

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