DataVXACS Applied Materials & InterfacesPaper
journal article·2016-07-13

A Multifunctional PB@mSiO2–PEG/DOX Nanoplatform for Combined Photothermal–Chemotherapy of Tumor

Yun Yan Su, Zhaogang Teng, Hui Yao, Shou Ju Wang, Ying Tian, Yun Lei Zhang, Wen Fei Liu, Wei Tian, Li Juan Zheng, Nan Lu, Qian Qian Ni, Xiao Dan Su, Yu Xia Tang, Jing Sun, Ying Liu, Jiang Wu, Gui Fen Yang, Guang Ming Lu, Long Jiang Zhang

ACS Applied Materials & Interfaces· Volume 8· Issue 27
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Source abstract

Abstract

In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@mSiO2-PEG nanocubes. The PB@mSiO2-PEG nanocubes have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) in the PB@mSiO2-PEG nanocubes, the constructured PB@mSiO2-PEG/DOX nanoplatforms show an excellent pH-responsive drug release character within 48 h, namely, an ultralow cumulative drug release amount of 3.1% at pH 7.4 and a high release amount of 46.6% at pH 5.0. Upon near-infrared laser irradiation, the PB@mSiO2-PEG/DOX nanoplatforms show an enhanced synergistic photothermal and chemical therapeutic efficacy for breast cancer than solo photothermal therapy or chemotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, People’s Republic of China

Department of Hepatopancreatobiliary Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, People’s Republic of China

Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210046, People’s Republic of China

Funding

Ministry of Science and Technology of the People's Republic of China · China Postdoctoral Science Foundation · National Natural Science Foundation of China

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