journal article·2020-09-23

Dual-Core Prebiotic Microcapsule Encapsulating Probiotics for Metabolic Syndrome

Cheng Zhao, Yujuan Zhu, Bin Kong, Yutong Huang, Dewen Yan, Hui Tan, Luoran Shang

ACS Applied Materials & Interfaces· Volume 12· Issue 38
Publisher page

Abstract

Designing strategies to utilize the synergistic effect of probiotics and prebiotics is a promising way in treating metabolic-related diseases. Here, inspired by the mutually promotable but mutually incompatible characteristics of Yin and Yang, dual-core microcapsules that encapsulate Lactobacillus and Bacillus subtilis into separate compartments were presented through electrostatically driven microfluidics. The microcapsules showed acid resistance and preserved probiotic activity. They also fostered the proliferation of probiotics while creating an anaerobic environment and promoted lactic acid fermentation without affecting each other. It has been demonstrated that the microcapsules could reduce inflammation, improve fat metabolism, and restore intestinal barrier functions, thus contributing to the treatment of metabolic syndrome in vivo. These features make the dual-core microcapsules an ideal candidate for treating metabolic syndrome and related diseases.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Gut microbiota and health · Probiotics and Fermented Foods · Polyamine Metabolism and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Endocrinology, Health Science Center, The First Affiliated Hospital, Shenzhen University, Shenzhen 518035, China

Department of Neurosurgery, The First Affiliated Hospital of Shenzhen University, Health Science Center of Shenzhen University, Shenzhen 518035, China

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

Macau University of Science and Technology, Macau 999078, China

Zhongshan-Xuhui Hospital, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China

Funding

Fudan University · China Postdoctoral Science Foundation · Natural Science Foundation of Jiangsu Province · Shenzhen Science and Technology Innovation Commission · Zhongshan Hospital · National Natural Science Foundation of China · Scientific Research Foundation of Southeast University · Joint Fund of Basic and Applied Basic Research Fund of Guangdong Province · Scientific Research Foundation of the Graduate School of Southeast University

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