journal article·2019-01-23

Biodegradable Polymer-Coated Multifunctional Graphene Quantum Dots for Light-Triggered Synergetic Therapy of Pancreatic Cancer

Chengbin Yang, Kok Ken Chan, Gaixia Xu, Mingjie Yin, Guimiao Lin, Xiaomei Wang, Wei-Jen Lin, Muhammad Danang Birowosuto, Shuwen Zeng, Takashi Ogi, Kikuo Okuyama, Fitri Aulia Permatasari, Ferry Iskandar, Chih-Kuang Chen, Ken-Tye Yong

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Abstract

In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small interfering ribonucleic acid (siRNA), resulting in the formation of GQD/DOX/BCPV/siRNA nanocomplexes. The resulting nanocomplexes have demonstrated high stability in physiologically mimicking media, excellent K-ras downregulation activity, and effective bioactivity inhibition for MiaPaCa-2 cells. More importantly, laser light was used to generate heat for the nanocomplexes via the photothermal effect to damage the cells, which was further employed to trigger the release of payloads from the nanocomplexes. Such triggered release function greatly enhanced the anticancer activity of the nanocomplexes. Preliminary colony formation study also suggested that GQD/DOX/BCPV/siRNA nanocomplexes are qualified carrier candidates in subsequent in vivo tests.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Graphene and Nanomaterials Applications · Carbon and Quantum Dots Applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore

Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Republic of China

CINTRA CNRS/NTU/THALES UMI 3288, Research Techno Plaza, 50 Nanyang Drive, Singapore 637553, Singapore

Department of Chemical Engineering, Graduate School of Engineering, Hiroshima University, Higashi Hiroshima 7398527, Japan

Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung 40132, Indonesia

Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 64002, Republic of China

Funding

Agency for Science, Technology and Research · Ministry of Education - Singapore · Ministry of Science and Technology, Taiwan · National Natural Science Foundation of China · Nanyang Technological University · National Healthcare Group · Nanyang Environment and Water Research Institute, Nanyang Technological University

References (63)

Show source-provided references
1. 10.3322/caac.2144210.3322/caac.21442 ↗
2. 10.1038/nrc359910.1038/nrc3599 ↗
3. 10.7150/thno.1133510.7150/thno.11335 ↗
4. 10.1021/acs.chemrev.7b0025810.1021/acs.chemrev.7b00258 ↗
5. 10.1002/adma.20170101310.1002/adma.201701013 ↗
6. 10.1002/adfm.20160170310.1002/adfm.201601703 ↗
7. 10.1039/c4tb01623h10.1039/c4tb01623h ↗
8. 10.1158/1541-7786.mcr-04-020610.1158/1541-7786.mcr-04-0206 ↗
9. 10.1007/s12274-017-1521-710.1007/s12274-017-1521-7 ↗
10. 10.1007/s12274-014-0642-510.1007/s12274-014-0642-5 ↗
11. 10.1021/am302030a10.1021/am302030a ↗
12. 10.1002/smll.20150335210.1002/smll.201503352 ↗
13. 10.1039/c4bm00306c10.1039/c4bm00306c ↗
14. 10.7150/ntno.1898910.7150/ntno.18989 ↗
15. 10.1039/c5cp03312h10.1039/c5cp03312h ↗
16. 10.1039/c7tb00747g10.1039/c7tb00747g ↗
17. 10.1039/c5ra27249a10.1039/c5ra27249a ↗
18. 10.1002/anie.20150119310.1002/anie.201501193 ↗
19. 10.1039/c8nr05164j10.1039/c8nr05164j ↗
20. 10.1016/j.biomaterials.2013.06.04510.1016/j.biomaterials.2013.06.045 ↗
21. 10.1021/acsami.8b0347710.1021/acsami.8b03477 ↗
22. 10.1021/mp400219u10.1021/mp400219u ↗
23. 10.1021/acsami.7b0556910.1021/acsami.7b05569 ↗
24. 10.1021/acsami.7b0882410.1021/acsami.7b08824 ↗
25. 10.1038/ncomms559610.1038/ncomms5596 ↗
26. 10.1016/j.biomaterials.2014.03.02110.1016/j.biomaterials.2014.03.021 ↗
27. 10.2147/ijn.s9186410.2147/ijn.s91864 ↗
28. 10.1038/ncomms635710.1038/ncomms6357 ↗
29. 10.1039/c4ra09159k10.1039/c4ra09159k ↗
30. 10.1021/acsanm.8b0049710.1021/acsanm.8b00497 ↗
31. 10.7150/thno.1138710.7150/thno.11387 ↗
32. 10.1038/srep2104210.1038/srep21042 ↗
33. 10.1515/ntrev-2017-019910.1515/ntrev-2017-0199 ↗
34. 10.1002/adma.20130218910.1002/adma.201302189 ↗
35. 10.1021/mp300666s10.1021/mp300666s ↗
36. 10.1016/j.biomaterials.2013.08.06310.1016/j.biomaterials.2013.08.063 ↗
37. 10.1039/c3nr05559k10.1039/c3nr05559k ↗
38. 10.1039/c6nr00996d10.1039/c6nr00996d ↗
39. 10.1002/adhm.20120009410.1002/adhm.201200094 ↗
40. 10.1039/c3bm60325c10.1039/c3bm60325c ↗
41. 10.1002/adma.20120078510.1002/adma.201200785 ↗
42. 10.1007/s12274-014-0698-210.1007/s12274-014-0698-2 ↗
43. 10.1007/s12274-014-0620-y10.1007/s12274-014-0620-y ↗
44. 10.1007/s12274-016-1183-x10.1007/s12274-016-1183-x ↗
45. 10.1007/s12274-014-0493-010.1007/s12274-014-0493-0 ↗
46. 10.1002/anie.20170868910.1002/anie.201708689 ↗
47. 10.1002/smll.20120176510.1002/smll.201201765 ↗
48. 10.1002/adfm.20150006110.1002/adfm.201500061 ↗
49. 10.1073/pnas.171442111510.1073/pnas.1714421115 ↗
50. 10.1002/adma.20150379910.1002/adma.201503799 ↗
51. 10.1002/adfm.20160338110.1002/adfm.201603381 ↗
52. 10.1088/0957-4484/26/36/36510110.1088/0957-4484/26/36/365101 ↗
53. 10.1113/expphysiol.2012.06585410.1113/expphysiol.2012.065854 ↗
54. 10.1016/j.canlet.2010.06.01210.1016/j.canlet.2010.06.012 ↗
55. 10.1038/nprot.2006.33910.1038/nprot.2006.339 ↗
56. 10.1039/c3bm60325c10.1039/c3bm60325c ↗
57. 10.1016/j.addr.2016.06.01110.1016/j.addr.2016.06.011 ↗
58. 10.1038/nrd274210.1038/nrd2742 ↗
59. 10.1016/j.progpolymsci.2016.09.00810.1016/j.progpolymsci.2016.09.008 ↗
60. 10.1016/j.canlet.2014.10.00810.1016/j.canlet.2014.10.008 ↗
61. 10.1016/s1470-2045(14)70063-410.1016/s1470-2045(14)70063-4 ↗
62. 10.3892/ijo.2015.323010.3892/ijo.2015.3230 ↗
63. 10.3389/fbioe.2016.0001210.3389/fbioe.2016.00012 ↗