Biodegradable Natural Product-Based Nanoparticles for Near-Infrared Fluorescence Imaging-Guided Sonodynamic Therapy

Xiuli Zheng; Weimin Liu; Jiechao Ge; Qingyan Jia; Fuchun Nan; Ying Ding; Jiasheng Wu; Wenjun Zhang; Chun-Sing Lee; Pengfei Wang

doi:10.1021/acsami.9b03270

journal article·2019-05-22

Biodegradable Natural Product-Based Nanoparticles for Near-Infrared Fluorescence Imaging-Guided Sonodynamic Therapy

Xiuli Zheng, Weimin Liu, Jiechao Ge, Qingyan Jia, Fuchun Nan, Ying Ding, Jiasheng Wu, Wenjun Zhang, Chun-Sing Lee, Pengfei Wang

ACS Applied Materials & Interfaces· Volume 11· Issue 20

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Source abstract

Abstract

Natural products show high potential for clinical translation because of their specific biological activities and molecular structure diversities. Sonosensitizers that originate from natural products play a crucial role as anti-inflammatory and anticancer agents. Herein, hypocrellin-derivative nanoparticles (APHB NPs) were constructed for synchronous near-infrared fluorescence (NIR FL) imaging and sonodynamic therapy (SDT) for deep-seated tumors in vivo. The prepared APHB NPs exhibit excellent water solubility, FL in the NIR region, and effective reactive oxygen species generation under ultrasound stimulation. Furthermore, the APHB NPs show excellent biocompatibility, suitable biodegradation rate, and enhanced tumor accumulation. Therefore, the APHB NPs exhibit promising clinical potential as novel safe and precise NIR FL imaging and SDT agents for deep-seated tumor therapy.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Biomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China

School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China

Center of Super-Diamond and Advanced Films (COSDAF) & Department of Materials Science and Engineering, City University of Hong Kong, Kowloon 999077, Hong Kong SAR, People’s Republic of China

Funding

National Natural Science Foundation of China · Chinese Academy of Sciences

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