journal article·2023-04-12

Flexible, Breathable, and Self-Powered Patch Assembled of Electrospun Polymer Triboelectric Layers and Polypyrrole-Coated Electrode for Infected Chronic Wound Healing

Qiwen Tang, Qi Ke, Qi Chen, Xinyi Zhang, Jianyu Su, Chengyun Ning, Liming Fang

ACS Applied Materials & Interfaces· Volume 15· Issue 14
Publisher page

Abstract

Chronic wound healing is often impaired by bacterial infection and weak trans-epithelial potential. Patches with electrical stimulation and bactericidal activity may solve this problem. However, inconvenient power and resistant antibiotics limit their application. Here, we proposed a self-powered and intrinsic bactericidal patch based on a triboelectric nanogenerator (TENG). Electrospun polymer tribo-layers and a chemical vapor-deposited polypyrrole electrode are assembled as the TENG, offering the patch excellent flexibility, breathability, and wettability. Electrical stimulations by harvesting mechanical motions and positive charges on the polypyrrole surface kill over 96% of bacteria due to their synergistic effects on cell membrane disruption. Moreover, the TENG patch promotes infected diabetic rat skin wounds to heal within 2 weeks. Cell culture and animal tests suggest that electrical stimulation enhances gene expression of growth factors for accelerated wound healing. This work provides new insights into the design of wearable and multifunctional electrotherapy devices for chronic wound treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Planarian Biology and Electrostimulation · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science and Engineering, South China University of Technology, Wushan 381, Tianhe District, Guangzhou 510641, China

National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou 510006, China

Guangdong Provincial Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou 510006, China

China-Singapore International Joint Research Institute, China-Singapore Smart Park, Huangpu District, Guangzhou 510555, China

Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, South China University of Technology, Wushan 381, Tianhe District, Guangzhou 510641, China

Funding

National Natural Science Foundation of China · Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, South China University of Technology · Guangdong Basic and Applied Basic Research Foundation

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