journal article·2020-02-12Open access

Fabrication and Characterization of Drug-Loaded Conductive Poly(glycerol sebacate)/Nanoparticle-Based Composite Patch for Myocardial Infarction Applications

Nazanin Zanjanizadeh Ezazi, Rubina Ajdary, Alexandra Correia, Ermei Mäkilä, Jarno Salonen, Marianna Kemell, Jouni Hirvonen, Orlando J. Rojas, Heikki J. Ruskoaho, Hélder A. Santos

Abstract

Heart tissue engineering is critical in the treatment of myocardial infarction, which may benefit from drug-releasing smart materials. In this study, we load a small molecule (3i-1000) in new biodegradable and conductive patches for application in infarcted myocardium. The composite patches consist of a biocompatible elastomer, poly(glycerol sebacate) (PGS), coupled with collagen type I, used to promote cell attachment. In addition, polypyrrole is incorporated because of its electrical conductivity and to induce cell signaling. Results from the in vitro experiments indicate a high density of cardiac myoblast cells attached on the patches, which stay viable for at least 1 month. The degradation of the patches does not show any cytotoxic effect, while 3i-1000 delivery induces cell proliferation. Conductive patches show high blood wettability and drug release, correlating with the rate of degradation of the PGS matrix. Together with the electrical conductivity and elongation characteristics, the developed biomaterial fits the mechanical, conductive, and biological demands required for cardiac treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland

Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P.O. Box 16300, FI-00076 Aalto, Espoo, Finland

Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, FI-20014 Turku, Finland

Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland

Departments of Chemical & Biological Engineering, Chemistry, and Wood Science, The University of British Columbia, 2360 East Mall, Vancouver, British Columbia V6T 1Z3, Canada

Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, FI-00014 Helsinki, Finland

Helsinki Institute of Life Science (HiLIFE), University of Helsinki, FI-00014 Helsinki, Finland

Funding

Sigrid Jus?liuksen S??ti? · Terveyden Tutkimuksen Toimikunta · Tekes · H2020 European Research Council · Life Science Institute, University of Helsinki · Centre of Excellence in Molecular Engineering of Biosynthetic Hybrid Materials

References (52)

Show source-provided references
1. WHO. W.H.O. Cardiovascular Diseases (CVDs). https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (accessed May 17, 2017).
2. 10.1093/eurheartj/ehx62810.1093/eurheartj/ehx628 ↗
3. 10.1007/s12471-011-0211-410.1007/s12471-011-0211-4 ↗
4. 10.1016/j.biomaterials.2014.05.07810.1016/j.biomaterials.2014.05.078 ↗
5. 10.1016/j.ijpharm.2017.11.06510.1016/j.ijpharm.2017.11.065 ↗
6. 10.1089/ten.teb.2015.052310.1089/ten.teb.2015.0523 ↗
7. 10.1016/j.biomaterials.2015.01.06010.1016/j.biomaterials.2015.01.060 ↗
8. 10.1016/j.cardfail.2012.05.00610.1016/j.cardfail.2012.05.006 ↗
9. 10.1016/j.jacc.2007.02.05010.1016/j.jacc.2007.02.050 ↗
10. 10.1016/j.jconrel.2018.05.02310.1016/j.jconrel.2018.05.023 ↗
11. 10.2147/IJN.S18958710.2147/IJN.S189587 ↗
12. 10.1016/j.biomaterials.2016.03.04610.1016/j.biomaterials.2016.03.046 ↗
13. 10.1002/adfm.20170513410.1002/adfm.201705134 ↗
14. 10.1016/j.msec.2018.06.03610.1016/j.msec.2018.06.036 ↗
15. 10.1126/sciadv.aat936510.1126/sciadv.aat9365 ↗
16. 10.1038/nmat459010.1038/nmat4590 ↗
17. 10.1039/C5TB01048A10.1039/C5TB01048A ↗
18. 10.1016/j.biomaterials.2010.01.10810.1016/j.biomaterials.2010.01.108 ↗
19. 10.1016/j.msec.2013.04.05810.1016/j.msec.2013.04.058 ↗
20. 10.1016/j.biomaterials.2007.09.01010.1016/j.biomaterials.2007.09.010 ↗
21. 10.1039/C5PY01993A10.1039/C5PY01993A ↗
22. 10.1016/j.biomaterials.2013.04.04510.1016/j.biomaterials.2013.04.045 ↗
23. 10.1016/j.msec.2016.03.03510.1016/j.msec.2016.03.035 ↗
24. 10.1039/C7RA02796F10.1039/C7RA02796F ↗
25. 10.4330/wjc.v5.i3.2810.4330/wjc.v5.i3.28 ↗
26. 10.1007/BF0022844810.1007/BF00228448 ↗
27. 10.1016/j.actbio.2014.02.02310.1016/j.actbio.2014.02.023 ↗
28. 10.1039/C8TB01116H10.1039/C8TB01116H ↗
29. 10.1002/jbm.a.3320010.1002/jbm.a.33200 ↗
30. 10.1016/j.progpolymsci.2013.06.00310.1016/j.progpolymsci.2013.06.003 ↗
31. 10.1016/j.synthmet.2018.06.00310.1016/j.synthmet.2018.06.003 ↗
32. 10.1021/la303091k10.1021/la303091k ↗
33. 10.1007/s00204-018-2257-110.1007/s00204-018-2257-1 ↗
34. 10.1038/s41598-018-22830-810.1038/s41598-018-22830-8 ↗
35. 10.1021/acs.jmedchem.7b0081610.1021/acs.jmedchem.7b00816 ↗
36. 10.1002/smll.20170127610.1002/smll.201701276 ↗
37. 10.1089/ten.tea.2010.044110.1089/ten.tea.2010.0441 ↗
38. 10.1038/sj.bjp.070428810.1038/sj.bjp.0704288 ↗
39. 10.1039/C4NR02187H10.1039/C4NR02187H ↗
40. 10.1016/j.jcis.2017.08.03310.1016/j.jcis.2017.08.033 ↗
41. 10.1016/j.ijbiomac.2013.09.02810.1016/j.ijbiomac.2013.09.028 ↗
42. 10.1016/S0927-7765(99)00049-110.1016/S0927-7765(99)00049-1 ↗
43. 10.1016/0927-7765(96)01270-210.1016/0927-7765(96)01270-2 ↗
44. 10.3390/polym1010107810.3390/polym10101078 ↗
45. 10.1002/(SICI)1521-4095(200002)12:3<222::AID-ADMA222>3.0.CO;2-D10.1002/(SICI)1521-4095(200002)12:3<222::AID-ADMA222>3.0.CO;2-D ↗
46. 10.1186/s40824-016-0078-y10.1186/s40824-016-0078-y ↗
47. 10.1002/anie.20140275110.1002/anie.201402751 ↗
48. 10.1021/nn502704g10.1021/nn502704g ↗
49. 10.1038/nbt0602-60210.1038/nbt0602-602 ↗
50. 10.1016/j.progpolymsci.2012.05.00310.1016/j.progpolymsci.2012.05.003 ↗
51. 10.3390/polym1102035010.3390/polym11020350 ↗
52. 10.1093/rb/rbx00910.1093/rb/rbx009 ↗