DataVXACS Applied Materials & InterfacesPaper
journal article·2018-12-26

Magnetic Cell–Scaffold Interface Constructed by Superparamagnetic IONP Enhanced Osteogenesis of Adipose-Derived Stem Cells

Huimin Chen, Jianfei Sun, Zibin Wang, Yi Zhou, Zhichao Lou, Bo Chen, Peng Wang, Zhirui Guo, Hui Tang, Junqing Ma, Yang Xia, Ning Gu, Feimin Zhang

ACS Applied Materials & Interfaces· Volume 10· Issue 51
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Source abstract

Abstract

One of the key factors in tissue engineering and regenerative medicine is to optimize the interaction between seed cells and scaffolds such that the cells can grow in naturally biomimetic conditions. Their similarity to macromolecules and many unique properties mean that functional nanoparticles have promising potential for the modification and improvement of traditional scaffolds to obtain excellent biocompatibility, tunable stiffness, physical sensing, and stimulus-response capabilities. In the present study, we report magnetic poly(lactic- co-glycolic acid)/polycaprolactone (PLGA/PCL) scaffolds that were fabricated using a combination of the electrospinning technique and layer-by-layer assembly of superparamagnetic iron oxide nanoparticles (IONPs). PLGA/PCL scaffolds assembled with gold nanoparticles were prepared using the same method for comparison. The results showed that the assembled film of nanoparticles on the surface greatly enhanced the hydrophilicity and increased the elastic modulus of the scaffold, which subsequently improved the osteogenesis of the stem cells. Furthermore, the magnetic property of the IONPs proved to be the key factor in enhancing osteogenic differentiation, which explained the superior osteogenic capacity of the magnetic scaffolds compared with that of the gold nanoparticle-assembled scaffold. These results demonstrated the importance of magnetic nanomaterials as a bioactive interface between cells and scaffolds and will promote the design of biomaterials to improve tissue engineering and regenerative medicine efficacy.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China

Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China

Analysis and Test Center, Nanjing Medical University Nanjing, Jiangsu 211166, China

Yixing People’s Hospital, Yixing, Jiangsu 214200, China

College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, Jiangsu 210037, China

Materials Science and Devices Institute, Suzhou University of Science and Technology, Suzhou, Jiangsu 215009, China

Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China

Department of Geriatrics, The Second Affiliated Hospital, Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing, Jiangsu 210011, China

Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, Jiangsu 215123, China

Funding

Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · the Southeast University-Nanjing Medical University Cooperative Research Project · Jiangsu Medical Youth Talent · a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions · Collaborative Innovation Centre of Suzhou Nano Science and Technology · the National Key R&D Program of China · Qing Lan Project

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