journal article·2017-09-27Open access

Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8–Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment

Li Yan, Xianfeng Chen, Zhigang Wang, Xiujuan Zhang, Xiaoyue Zhu, Mengjiao Zhou, Wei Chen, Longbiao Huang, Vellaisamy A. L. Roy, Peter K. N. Yu, Guangyu Zhu, Wenjun Zhang

Abstract

Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8-poly(acrylic acid sodium salt) (ZIF-8-PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8-PAAS nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal-organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Covalent Organic Framework Applications · Nanomaterials for catalytic reactions

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics (SIIA), Chengdu University, Chengdu, Sichuan 610052, People’s Republic of China

Center of Super-Diamond and Advanced Films (COSDAF) and Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong SAR

School of Engineering, Institute for Bioengineering, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JL, United Kingdom

Department of Chemistry, City University of Hong Kong, Hong Kong SAR

Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, People’s Republic of China

Department of Physics, City University of Hong Kong, Hong Kong SAR

Funding

Royal Society · Research Grants Council, University Grants Committee · School of Engineering, University of Edinburgh

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