DataVXACS Applied Materials & InterfacesPaper
journal article·2015-08-19

In Situ Biosynthesis of Fluorescent Platinum Nanoclusters: Toward Self-Bioimaging-Guided Cancer Theranostics

Donghua Chen, Chunqiu Zhao, Jing Ye, Qiwei Li, Xiaoli Liu, Meina Su, Hui Jiang, Christian Amatore, Matthias Selke, Xuemei Wang

ACS Applied Materials & Interfaces· Volume 7· Issue 32
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Source abstract

Abstract

Among the noble-metal clusters, very few reports about platinum clusters were used as bioimaging probes of tumors except as a reducing catalyst. It is first established herein that the biocompatible platinum nanoclusters are spontaneously biosynthesized by cancerous cells (i.e., HepG2 (human hepatocarcinoma), A549 (lung cancer), and others) rather than noncancerous cells (i.e., L02 (human embryo liver cells)) when incubated with micromolar chloroplatinic acid solutions. These in situ biosynthesized platinum nanoclusters could be readily realized in a biological environment and emit a bright fluorescence at 460 nm, which could be further utilized to facilitate an excellent cancer-cell-killing efficiency when combined with porphyrin derivatives for photothermal treatment. This raises the possibility of providing a promising and precise bioimaging strategy for specific fluorescent self-biomarking of tumor locations and realizing fluorescence imaging-guided photothermal therapy of tumors.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterialsCatalysis & surfaces

OpenAlex topics: Nanocluster Synthesis and Applications · Advanced Nanomaterials in Catalysis · Gold and Silver Nanoparticles Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China

CNRS UMR 8640 PASTEUR and LIA NanoBioCatEchem, Ecole Normale Supérieure-PSL Research University, Département de Chimie, Sorbonne Universités—UPMC Paris 6, 24 rue Lhomond, 75005 Paris, France

Department of Chemistry and Biochemistry, California State University, Los Angeles, California 90032, United States

Funding

Universit? Pierre et Marie Curie · Division of Human Resource Development · Ecole Normale Superieure · National Natural Science Foundation of China · Centre National de la Recherche Scientifique · Ministry of Science and Technology of the People's Republic of China · Major Science & Technology Project of Suzhou

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