DataVXACS Applied Materials & InterfacesPaper
journal article·2015-02-11Open access

Red Fluorescent Zinc Oxide Nanoparticle: A Novel Platform for Cancer Targeting

Hao Hong, Fei Wang, Yin Zhang, Stephen A. Graves, Savo Bou Zein Eddine, Yunan Yang, Charles P. Theuer, Robert J. Nickles, Xudong Wang, Weibo Cai

ACS Applied Materials & Interfaces· Volume 7· Issue 5
Publisher pageOpen full text
Source abstract

Abstract

Multifunctional zinc oxide (ZnO) nanoparticles (NPs) with well-integrated multimodality imaging capacities have generated increasing research interest in the past decade. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. Here we developed novel red fluorescent ZnO NPs and described the successful conjugation of 64Cu (t1/2=12.7 h) and TRC105, a chimeric monoclonal antibody against CD105, to these ZnO NPs via well-developed surface engineering procedures. The produced dual-modality ZnO NPs were readily applicable for positron emission tomography (PET) imaging and fluorescence imaging of the tumor vasculature. Their pharmacokinetics and tumor-targeting efficacy/specificity in mice bearing murine breast 4T1 tumor were thoroughly investigated. ZnO NPs with dual-modality imaging properties can serve as an attractive candidate for future cancer theranostics.
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Research context

Nanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin 53705-2275, United States

Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705-2275, United States

Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705-2275, United States

Faculty of Medicine and Medical Center, American University of Beirut, Beirut 11072020, Lebanon

TRACON Pharmaceuticals, San Diego, California 92122, United States

University of Wisconsin Carbone Cancer Center, Madison, Wisconsin 53705-2275, United States

Funding

National Cancer Institute · National Institute of Biomedical Imaging and Bioengineering · Advanced Research Projects Agency - Energy · Congressionally Directed Medical Research Programs · American Cancer Society · University of Wisconsin-Madison

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