journal article·2022-06-15

Bioactive Injectable Hydrogel Dressings for Bacteria-Infected Diabetic Wound Healing: A “Pull–Push” Approach

Kunbao Zhang, Chao Yang, Chuanxu Cheng, Chengxin Shi, Madi Sun, Hanze Hu, Tongfei Shi, Xuenian Chen, Xuan He, Xiao Zheng, Mingqiang Li, Dan Shao

ACS Applied Materials & Interfaces· Volume 14· Issue 23
Publisher page

Abstract

Chronic diabetic wound healing remains a challenge due to the existence of excessive danger molecules and bacteria in the inflammatory microenvironment. There is an urgent need for advanced wound dressings that target both inflammation and infection. Here, a bioactive hydrogel without loading any anti-inflammatory ingredients is rationally designed to achieve a “Pull–Push” approach for efficient and safe bacteria-infected diabetic wound healing by integrating danger molecule scavenging (Pull) with antibiotic delivery (Push) in the inflammatory microenvironment. The cationic hydrogel, termed the OCMC-Tob/PEI hydrogel, is fabricated by the conjugation of polyethylenimine (PEI) and tobramycin (Tob) on an oxidized carboxymethyl cellulose (OCMC) backbone via the Schiff base reaction with injectable, self-healing, and biocompatible properties. The OCMC-Tob/PEI hydrogel not only displays the remarkable capability of capturing multiple negatively charged danger molecules (e.g., cell-free DNA, lipopolysaccharides, and tumor necrosis factor-α) to ameliorate anti-inflammation effects but also achieves controllable long-term antibacterial activity by the pH-sensitive release of Tob. Consequently, this multifunctional hydrogel greatly expedites the wound closure rate with combined anti-inflammation and anti-infection effects on Pseudomonas aeruginosa-infected diabetic wounds. Our work provides a highly versatile treatment approach for chronic diabetic wounds and a promising dressing for regenerative medicine.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Wound Healing and Treatments · Diabetic Foot Ulcer Assessment and Management · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 511442, China

National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong 510006, China

Guangdong Provincial Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China

Department of Biomedical Engineering, Columbia University, New York, New York 10027, United States

Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, China

Department of Plastic and Aesthetic Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310000, China

Institutes for Life Sciences, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China

Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China

Funding

China Postdoctoral Science Foundation · Central University Basic Research Fund of China · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Guangzhou Basic and Applied Basic Research Foundation

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