DataVXACS Applied Materials & InterfacesPaper
journal article·2018-05-09

In Vivo Targeted, Responsive, and Synergistic Cancer Nanotheranostics by Magnetic Resonance Imaging-Guided Synergistic High-Intensity Focused Ultrasound Ablation and Chemotherapy

Hailin Tang, Yuan Guo, Li Peng, Hui Fang, Zhigang Wang, Yuanyi Zheng, Haitao Ran, Yu Chen

ACS Applied Materials & Interfaces· Volume 10· Issue 18
Publisher page
Source abstract

Abstract

-weighted magnetic resonance imaging. By virtue of the thermal effect as generated by HIFU, liquid-gas phase transition of perfluorohexane (PFH) in nanocomposites was induced to generate PFH microbubbles, which achieved the contrast-enhanced ultrasound imaging and significantly improved the HIFU ablation efficacy. The loaded anticancer drugs could be released from the nanocomposites in a controllable manner (both pH and HIFU responsiveness). These multifunctional nanocomposites have been demonstrated to efficiently suppress the tumor growth based on the enhanced and synergistic chemotherapy and HIFU ablation, providing an efficient theranostic nanoplatform for cancer treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Ultrasound and Hyperthermia Applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound, Tongde Hospital of Zhejiang Province, Hangzhou 310012, P. R. China

Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing 400010, P. R. China

Shanghai Institute of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Shanghai Sixth People’s Hospital, Shanghai 200233, P. R. China

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China

Funding

China Association for Science and Technology · Ministry of Science and Technology of the People's Republic of China · Science and Technology Department of Zhejiang Province · National Natural Science Foundation of China · Department of Health of Zhejiang Province

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