journal article·2017-08-30

Hyperbranched Phosphorescent Conjugated Polymer Dots with Iridium(III) Complex as the Core for Hypoxia Imaging and Photodynamic Therapy

Zhiying Feng, Peng Tao, Liang Zou, Pengli Gao, Yuan Liu, Xing Liu, Hua Wang, Shujuan Liu, Qingchen Dong, Jie Li, Bingshe Xu, Wei Huang, Wai-Yeung Wong, Qiang Zhao

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Abstract

Real-time monitoring of the contents of molecular oxygen (O 2 ) in tumor cells is of great significance in early diagnosis of cancer. At the same time, the photodynamic therapy (PDT) could be realized by highly toxic singlet oxygen ( 1 O 2 ) generated in situ during the O 2 sensing, making it one of the most promising methods for cancer therapy. Herein, the iridium(III) complex cored hyperbranched phosphorescent conjugated polymer dots with the negative charges for hypoxia imaging and highly efficient PDT was rationally designed and synthesized. The incomplete energy transfer between the polyfluorene and the iridium(III) complexes realized the ratiometric sensing of O 2 for the accurate measurements. Furthermore, the O 2 -dependent emission lifetimes are also used in photoluminescence lifetime imaging and time-gated luminescence imaging for eliminating the autofluorescence remarkably to enhance the signal-to-noise ratio of imaging. Notably, the polymer dots designed could generate the 1 O 2 effectively in aqueous solution, and the image-guided PDT of the cancer cells was successfully realized and investigated in detail by confocal laser scanning microscope. To the best of our knowledge, this represents the first example of the iridium(III) complex cored hyperbranched conjugated polymer dots with the negative charges for both hypoxia imaging and PDT of cancer cells simultaneously.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Analytical Chemistry and Sensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Center of Advanced Materials Science and Technology and MOE Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Taiyuan 030024, People’s Republic of China

Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210023, People’s Republic of China

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, People’s Republic of China

Funding

Research Grants Council, University Grants Committee · National Natural Science Foundation of China · Hong Kong Polytechnic University · Central Committee of the Communist Party of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · Scientific and Technological Innovation Teams of Colleges and Universities of Jiangsu Province · Key Innovative Research Team in Science and Technology of Shanxi Province · State Key Laboratory of Bioelectronics, Southeast University

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