journal article·2015-06-17

Chirality-based Au@Ag Nanorod Dimers Sensor for Ultrasensitive PSA Detection

Lijuan Tang, Si Li, Liguang Xu, Wei Ma, Hua Kuang, Libing Wang, Chuanlai Xu

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Abstract

A novel biosensor for ultrasensitive detection of prostate-specific antigen (PSA) was established based on gold nanorod (Au NR) dimers assembly. The circular dichroism signal was significantly amplified by a silver shell depositing on the surface of the Au NR dimers. A low limit of detection of 0.076 aM and high specificity were observed within the range of 0.1 to 50 aM target PSA. The developed biosensor has the potential to serve as a general platform for the detection of cancer biomarkers.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China

Funding

Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Jiangsu Province · Ministry of Finance · National Natural Science Foundation of China

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