Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation
Source abstract
Abstract
Mg and its alloys evince strong candidature for biodegradable bone implants, cardiovascular stents, and wound closing devices. However, their rapid degradation rate causes premature implant failure, constraining clinical applications. Bio-functional surface coatings have emerged as the most competent strategy to fulfill the diverse clinical requirements, besides yielding effective corrosion resistance. This article reviews the progress of biodegradable and advanced surface coatings on Mg alloys investigated in recent years, aiming to build up a comprehensive knowledge framework of coating techniques, processing parameters, performance measures in terms of corrosion resistance, adhesion strength, and biocompatibility. Recently developed conversion and deposition type surface coatings are thoroughly discussed by reporting their essential therapeutic responses like osteogenesis, angiogenesis, cytocompatibility, hemocompatibility, anti-bacterial, and controlled drug release towards in-vitro and in-vivo study models. The challenges associated with metallic, ceramic and polymeric coatings along with merits and demerits of various coatings have been illustrated. The use of multilayered hybrid coating comprising a unique combination of organic and inorganic components has been emphasized with future perspectives to obtain diverse bio-functionalities in a facile single coating system for orthopedic implant applications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · MXene and MAX Phase Materials · Corrosion Behavior and Inhibition
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Anisotropy characteristics of microstructures for bone substitutes and porous implants with application of additive manufacturing in orthopaedic10.1016/j.matdes.2020.108608 ↗
2. Recent progress in in vivo studies and clinical applications of magnesium based biodegradable implants – a review10.1016/j.jma.2020.11.001 ↗
3. Recent advances in biodegradation controls over Mg alloys for bone fracture management: a review10.1016/j.jmst.2018.10.008 ↗
4. Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg
5. High-purity weight-bearing magnesium screw: translational application in the healing of femoral neck fracture10.1016/j.biomaterials.2020.119829 ↗
6. Biodegradable Mg alloys for orthopedic implants – a review10.1016/j.jma.2021.06.024 ↗
7. Tissue responses after implantation of biodegradable Mg alloys evaluated by multimodality 3D micro-bioimaging in vivo10.1002/jbm.a.37148 ↗
8. Visual and antibacterial magnesium implants with low biocorrosion and bioactive surface for in vivo tracking and treating MRSA infection10.1016/j.cej.2021.129198 ↗
9. In vitro and in vivo degradation assessment and preventive measures of biodegradable Mg alloys for biomedical applications10.1002/jbm.a.37297 ↗
10. Potential bioactive coating system for high-performance absorbable magnesium bone implants
11. Biodegradable metals10.1016/j.mser.2014.01.001 ↗
12. Treatment options for aseptic tibial diaphyseal nonunion: a review of selected studies10.1302/2058-5241.5.190077 ↗
13. Influence of the amount of intermetallics on the degradation of Mg-Nd alloys under physiological conditions10.1016/j.actbio.2020.11.050 ↗
14. Biosafety and biodegradation studies of AZ31B magnesium alloy carotid artery stent in vitro and in vivo10.1002/jbm.b.34907 ↗
15. Anticancer effect of biodegradable magnesium on hepatobiliary carcinoma: an in vitro and in vivo study10.1021/acsbiomaterials.1c00288 ↗
16. In vivo and in vitro evaluation of a biodegradable magnesium vascular stent designed by shape optimization strategy10.1016/j.biomaterials.2019.119414 ↗
17. Protein adsorption on magnesium and its alloys: a review10.1016/j.apsusc.2018.08.173 ↗
18. Role of protein adsorption in the bio corrosion of metallic implants – a review10.1016/j.colsurfb.2019.01.038 ↗
19. Dynamic degradation of porous magnesium under a simulated environment of human cancellous bone10.1016/j.corsci.2016.08.017 ↗
20. Degradation and biocompatibility of AZ31 magnesium alloy implants in vitro and in vivo: a micro-computed tomography study in rats10.3390/ma13020473 ↗
21. In vitro and in vivo studies on biomedical magnesium low-alloying with elements gadolinium and zinc for orthopedic implant applications10.1021/acsami.7b15498 ↗
22. In vitro and in vivo degradation behavior and biocompatibility evaluation of microarc oxidation-fluoridated hydroxyapatite-coated Mg-Zn-Zr-Sr alloy for bone application10.1021/acsbiomaterials.9b00564 ↗
23. Magnesium degradation under physiological conditions – best practice
24. Challenges and opportunities for biodegradable magnesium alloy implants10.1080/10667857.2017.1377973 ↗
25. Microstructures, mechanical and cytocompatibility of degradable Mg-Zn based orthopedic biomaterials10.1016/j.matdes.2014.01.031 ↗
26. Mg bone implant: features, developments and perspectives10.1016/j.matdes.2019.108259 ↗
27. The current trends of Mg alloys in biomedical applications—a review10.1002/jbm.b.34290 ↗
28. Amorphous magnesium alloy with high corrosion resistance fabricated by laser powder bed fusion10.1016/j.jallcom.2021.163247 ↗
29. Degradability and in vivo biocompatibility of micro-alloyed Mg-Ca-La alloys as orthopedic implants10.1016/j.matlet.2021.131510 ↗
30. Effect of microstructure on corrosion behavior of Mg–Sr alloy in Hank's solution10.1007/s40195-018-0750-4 ↗
31. Review of Mg alloy corrosion rates10.1016/j.jma.2020.08.002 ↗
32. Mechanical, corrosion, and biocompatibility properties of Mg-Zr-Sr-Sc alloys for biodegradable implant applications10.1016/j.actbio.2019.12.001 ↗
33. Kumar · 2021 · 557
34. Electrochemical techniques for monitoring the biodegradability of nanocomposite Mg-alloy/HA for repairing bone fracture10.1016/j.jmrt.2022.03.040 ↗
35. Magnesium matrix composites for biomedical applications: a review10.1016/j.jma.2018.11.001 ↗
36. Design of magnesium alloys with controllable degradation for biomedical implants: from bulk to surface10.1016/j.actbio.2016.09.005 ↗
37. Biodegradable magnesium alloys for orthopaedic applications: a review on corrosion, biocompatibility and surface modifications10.1016/j.msec.2016.06.020 ↗
38. Experimental investigation and optimization of wire electrical discharge machining for surface characteristics and corrosion rate of biodegradable Mg alloy10.1007/s11665-020-04905-8 ↗
39. Surface modification of biodegradable Mg-4Zn alloy using PMEDM: an experimental investigation, optimization and corrosion analysis
40. Coatings on Mg alloys and their mechanical properties: a review10.1016/j.jmst.2017.12.004 ↗
41. Micro‐arc oxidation of magnesium alloys: a review10.1016/j.jmst.2021.11.053 ↗
42. Effect of grain refinement on corrosion rate, mechanical and machining behavior of friction stir processed ZE41 Mg alloy10.1007/s12666-018-1467-9 ↗
43. Advances in coatings on biodegradable magnesium alloys10.1016/j.jma.2019.09.008 ↗
44. Surface design of Mg-Zn alloy temporary orthopaedic implants: tailoring wettability and biodegradability using laser surface melting10.1016/j.surfcoat.2018.05.017 ↗
45. Microstructure and corrosion behavior of laser surface-treated AZ31B Mg bio-implant material10.1007/s10103-017-2174-1 ↗
46. Enhanced corrosion resistance of AZ91 magnesium alloy through refinement and homogenization of surface microstructure by friction stir processing10.1016/j.corsci.2018.04.028 ↗
47. Apatite formation and weight loss study in EDMed perforated AZ31 Mg-alloy10.1016/j.jma.2017.08.008 ↗
48. The effects of laser shock peening on the mechanical properties and biomedical behavior of AZ31B magnesium alloy10.1016/j.surfcoat.2018.02.009 ↗
49. In vitro and in vivo corrosion, mechanical properties and biocompatibility evaluation of MgF2-coated Mg-Zn-Zr alloy as cancellous screws10.1016/j.msec.2017.02.168 ↗
50. Deposition of nanostructured fluorine-doped hydroxyapatite-polycaprolactone duplex coating to enhance the mechanical properties and corrosion resistance of Mg alloy for biomedical applications10.1016/j.msec.2015.11.057 ↗
51. Protection of magnesium alloys: from physical barrier coating to smart self-healing coating10.1016/j.jallcom.2020.157010 ↗
52. Recent advances in anti-inflammatory strategies for implantable biosensors and medical implants10.1007/s13206-020-4105-7 ↗
53. Composition and design of nanofibrous scaffolds of Mg/Se- hydroxyapatite/graphene oxide @ ε-polycaprolactone for wound healing applications10.1016/j.jmrt.2020.04.094 ↗
54. Coatings for biodegradable magnesium-based supports for therapy of vascular disease: a general view10.1016/j.msec.2019.04.032 ↗
55. Hybrid fracture fixation systems developed for orthopaedic applications: a general review
56. Fabrication of magnesium/zinc-metal organic framework on titanium implants to inhibit bacterial infection and promote bone regeneration10.1016/j.biomaterials.2019.05.008 ↗
57. Determination of the chemical mechanism of chromate conversion coating on magnesium alloys EV31A10.1016/j.apsusc.2014.01.162 ↗
58. Microstructure and electrochemical behavior of cerium conversion coating modified with silane agent on magnesium substrates10.1016/j.apsusc.2016.03.150 ↗
59. The role of post-treatment of an ecofriendly cerium nanostructure Conversion coating by green corrosion inhibitor on the adhesion and corrosion protection properties of the epoxy coating10.1016/j.porgcoat.2017.09.015 ↗
60. Enhanced corrosion performance of magnesium phosphate conversion coating on AZ31 magnesium alloy10.1016/S1003-6326(17)60127-4 ↗
61. Duplex-layered manganese phosphate conversion coating on AZ31 Mg alloy and its initial formation mechanism10.1016/j.corsci.2013.07.024 ↗
62. Effect of pH value and preparation temperature on the formation of magnesium phosphate conversion coatings on AZ31 magnesium alloy10.1016/j.apsusc.2019.05.309 ↗
63. Effect of phosphating solution pH value on the formation of phosphate conversion coatings for corrosion behaviors on AZ91D10.1007/s42114-021-00222-3 ↗
64. Controlling initial biodegradation of magnesium by a biocompatible strontium phosphate conversion coating10.1016/j.actbio.2013.11.016 ↗
65. Designing for the chemical conversion coating with high corrosion resistance and low electrical contact resistance on AZ91D magnesium alloy10.1016/j.corsci.2018.02.051 ↗
66. Ratio of total acidity to pH value of coating bath: a new strategy towards phosphate conversion coatings with optimized corrosion resistance for magnesium alloys10.1016/j.corsci.2019.01.046 ↗
67. Biomedical coatings on magnesium alloys - a review10.1016/j.actbio.2012.04.012 ↗
68. Flash-PEO as an alternative to chromate conversion coatings for corrosion protection of Mg alloy10.1016/j.corsci.2020.109189 ↗
69. Improvement of electrochemical corrosion characteristics of AZ61 magnesium alloy with unconventional fluoride conversion coatings10.1016/j.surfcoat.2018.10.038 ↗
70. Cationic and anionic substitutions in hydroxyapatite
71. Modification of Ti6Al4V implant surfaces by biocompatible TiO2/PCL hybrid layers prepared via sol-gel dip coating: structural characterization, mechanical and corrosion behavior10.1016/j.msec.2016.12.046 ↗
72. The mechanical properties and corrosion behavior of double-layered nano hydroxyapatite-polymer coating on Mg-Ca alloy10.1007/s11665-015-1661-4 ↗
73. Realization and characterization of double-layer Ca-P coating on WE43 Mg alloy for biomedical applications10.1016/j.surfcoat.2020.126091 ↗
74. Advances in synthesis of calcium phosphate crystals with controlled size and shape10.1016/j.actbio.2014.06.017 ↗
75. HA coating on Mg alloys for biomedical applications: a review10.1016/j.jma.2020.05.003 ↗
76. Calcium phosphate coatings enhance biocompatibility and degradation resistance of magnesium alloy: correlating in vitro and in vivo studies
77. Chemically depleting the noble impurities from AZ91-T4 magnesium alloy: a new and efficient pretreatment method to improve the corrosion resistance of phosphate conversion coatings10.1016/j.corsci.2021.109725 ↗
78. The formation mechanism and corrosion resistance of a composite phosphate conversion film on AM60 alloy10.3390/ma11030402 ↗
79. Investigation on the corrosion behavior of lanthanum phosphate coatings on AZ31 Mg alloy obtained through chemical conversion technique10.1016/j.jallcom.2019.01.121 ↗
80. The study of corrosion behavior of manganese-based conversion coating on LZ91 magnesium alloy: effect of addition of pyrophosphate and cerium10.1016/j.matdes.2020.108707 ↗
81. Interfacial study of the formation mechanism of corrosion resistant strontium phosphate coatings upon Mg-3Al-4.3Ca-0.1Mn10.1016/j.corsci.2019.02.024 ↗
82. Comparison of corrosion resistance and biocompatibility of magnesium phosphate (MgP), zinc phosphate (ZnP) and calcium phosphate (CaP) conversion coatings on Mg alloy10.1016/j.surfcoat.2020.125919 ↗
83. In vitro degradation and biomineralization ability of hydroxyapatite coated Mg-9Li-7Al-1Sn and Mg-9Li-5Al-3Sn-1Zn alloys10.1016/j.surfcoat.2017.06.027 ↗
84. The influence of alternating cyclic dynamic loads with different low frequencies on the bio-corrosion behaviors of AZ31B magnesium alloy in vitro
85. The formation mechanism and bio-corrosion properties of Ag/HA composite conversion coating on the extruded Mg-2Zn-1Mn-0.5Ca alloy for bone implant application10.1016/j.surfcoat.2017.06.023 ↗
86. Preparation and solubility of hydroxyapatite10.6028/jres.072A.052 ↗
87. Magnesium incorporated hydroxyapatite: synthesis and structural properties characterization10.1016/j.ceramint.2013.11.051 ↗
88. The corrosion protection afforded by rare earth conversion coatings applied to magnesium10.1016/S0010-938X(99)00076-1 ↗
89. Designing for the cerium-based conversion coating with excellent corrosion resistance on Mg–4Y–2Al magnesium alloy10.1002/maco.202012166 ↗
90. Rare earth-based materials for bone regeneration: breakthroughs and advantages10.1016/j.ccr.2021.214236 ↗
91. Preparation of yttrium-based rare earth conversion coating and its effect on corrosion resistance of AZ91D magnesium alloy10.20964/2017.01.53 ↗
92. Selenium conversion coating on AZ31 Mg alloy: a solution for improved corrosion rate and enhanced bio-adaptability10.1016/j.surfcoat.2019.124902 ↗
93. Anticancer activity of samarium-coated magnesium implants for immunocompromised patients10.1021/acsabm.0c00400 ↗
94. Robust corrosion resistance and self-healing characteristics of a novel Ce/Mn conversion coatings on EV31 magnesium alloys10.1016/j.apsusc.2020.145385 ↗
95. MgO-CeO 2 nanocomposite : efficient catalyst for the preparation of 2-aminothiophenes and10.1080/17415993.2018.1436710 ↗
96. Europium-doped cerium oxide nanoparticles for microglial amyloid beta clearance and homeostasis10.1021/acschemneuro.1c00847 ↗
97. Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering
98. Mixed valence state cerium metal organic framework with prominent oxidase-mimicking activity for ascorbic acid detection: mechanism and performance10.1016/j.colsurfa.2022.128610 ↗
99. Untangling the biological effects of cerium oxide nanoparticles: the role of surface valence states10.1038/srep15613 ↗
100. Behavioral deficits and neural damage of Caenorhabditis elegans induced by three rare earth elements10.1016/j.chemosphere.2017.04.068 ↗