journal article·2015-11-11Open access

Colloidal Gold–Collagen Protein Core–Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth

Ruirui Xing, Tifeng Jiao, Linyin Yan, Guanghui Ma, Lei Liu, Luru Dai, Junbai Li, Helmuth Möhwald, Xuehai Yan

Abstract

The biogenic synthesis of biomolecule-gold nanoconjugates is of key importance for a broad range of biomedical applications. In this work, a one-step, green, and condition-gentle strategy is presented to synthesize stable colloidal gold-collagen core-shell nanoconjugates in an aqueous solution at room temperature, without use of any reducing agents and stabilizing agents. It is discovered that electrostatic binding between gold ions and collagen proteins and concomitant in situ reduction by hydroxyproline residues are critically responsible for the formation of the core-shell nanoconjugates. The film formed by layer-by-layer assembly of such colloidal gold-collagen nanoconjugates can notably improve the mechanical properties and promote cell adhesion, growth, and differentiation. Thus, the colloidal gold-collagen nanoconjugates synthesized by such a straightforward and clean manner, analogous to a biomineralization pathway, provide new alternatives for developing biologically based hybrid biomaterials toward a range of therapeutic and diagnostic applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Polymer Surface Interaction Studies · Bone Tissue Engineering Materials · Collagen: Extraction and Characterization

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China

Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China

National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China

Institute of Advanced Materials, Jiangsu University, Zhenjiang 212013, Jiangsu, China

National Center for Nanoscience and Technology, Beijing 100190, China

Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, D-14476 Potsdam/Golm, Germany

Funding

Central Committee of the Communist Party of China · Chinese Academy of Sciences · Natural Science Foundation of Hebei Province · Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province · National Natural Science Foundation of China · Hebei Province

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