DataVXACS Applied Materials & InterfacesPaper
journal article·2022-03-09

Antibacterial Cascade Catalytic Glutathione-Depleting MOF Nanoreactors

Xi Zhou, Shuai Zhang, Yan Liu, Jiashen Meng, Muxue Wang, Yaoji Sun, Linbo Xia, Zhaozhi He, Wenxin Hu, Lei Ren, Zhiwei Chen, Xingcai Zhang

ACS Applied Materials & Interfaces· Volume 14· Issue 9
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Source abstract

Abstract

Nanozymes with peroxidase-like activity have great application potential in combating pathogenic bacterial infections and are expected to become an alternative to antibiotics. However, the near-neutral pH and high glutathione (GSH) levels in the bacterial infection microenvironment severely limit their applications in antibacterial therapy. In this work, a metal-organic framework (MOF)-based cascade catalytic glutathione-depleting system named MnFe2O4@MIL/Au&GOx (MMAG) was constructed. The MMAG cascade-catalyzed glucose to provide H+ and produces a large amount of toxic reactive oxygen species. In addition, MMAG consumed GSH, which can result in bacterial death more easily. Systematic antibacterial experiments illustrated that MMAG has superior antibacterial effects on both Gram-positive bacteria and Gram-negative bacteria.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen 361005, People’s Republic of China

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States

School of Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, People’s Republic of China

Harvard College, Harvard University, 209 Dunster Mail Center, 945 Memorial Drive, Cambridge, Massachusetts 02138, United States

Funding

China Scholarship Council · National Natural Science Foundation of China

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