A FRET-based Ratiometric Fluorescent Probe for Nitroxyl Detection in Living Cells
Source abstract
Abstract
HNO has recently been found to possess distinct biological functions from NO. Studying the biological functions of HNO calls for the development of sensitive and selective fluorescent probes. Herein, we designed and synthesized a FRET-based ratiometric probe to detect HNO in living cells. Our studies revealed that the probe is capable of detecting HNO in a rapid and ratiometric manner under physiological conditions. In bioimaging studies, the probe displayed a clear color change from blue to green when treated with HNO.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Molecular Sensors and Ion Detection · Sulfur Compounds in Biology · Nitric Oxide and Endothelin Effects
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, People’s Republic of China
Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, People’s Republic of China
Department of Biomedical Sciences, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, People’s Republic of China
Funding
National Natural Science Foundation of China
References (39)
Show source-provided references
1. Miranda K. M. · Proc. Natl. Acad. Sci. U.S.A. · 2003 · 100 · 919610.1073/pnas.1430507100 ↗
2. Ma X. L. · Proc. Natl. Acad. Sci. U.S.A. · 1999 · 96 · 1461710.1073/pnas.96.25.14617 ↗
3. DeMaster E. G. · Biochem. Pharmacol. · 1998 · 55 · 200710.1016/S0006-2952(98)00080-X ↗
4. Irvine J. C. · Hypertension · 2007 · 49 · 88510.1161/01.HYP.0000259328.04159.90 ↗
5. Paolocci N. · Proc. Natl. Acad. Sci. U.S.A. · 2001 · 98 · 1046310.1073/pnas.181191198 ↗
6. Switzer C. H. · Biochim. Biophys. Acta · 2009 · 1787 · 83510.1016/j.bbabio.2009.04.015 ↗
7. Lakowicz J. R. · 200610.1007/978-0-387-46312-4 ↗
8. Li X. · Chem. Rev. · 2014 · 114 · 59010.1021/cr300508p ↗
9. Yuan L. · Acc. Chem. Res. · 2013 · 46 · 146210.1021/ar300273v ↗
10. Rosenthal J. · J. Am. Chem. Soc. · 2010 · 132 · 553610.1021/ja909148v ↗
11. Royzen M. · J. Inorg. Biochem. · 2013 · 118 · 16210.1016/j.jinorgbio.2012.08.025 ↗
12. Zhou Y. · Org. Lett. · 2011 · 13 · 129010.1021/ol103077q ↗
13. McQuade L. E. · Inorg. Chem. · 2010 · 49 · 802510.1021/ic101054u ↗
14. Wrobel A. T. · J. Am. Chem. Soc. · 2014 · 136 · 469710.1021/ja500315x ↗
15. Tennyson A. G. · Polyhedron · 2007 · 26 · 462510.1016/j.poly.2007.04.003 ↗
16. Zhou Y. · Sens. Actuators, B · 2012 · 174 · 41410.1016/j.snb.2012.08.067 ↗
17. Cline M. R. · J. Phys. Org. Chem. · 2011 · 24 · 99310.1002/poc.1871 ↗
18. Kawai K. · J. Am. Chem. Soc. · 2013 · 135 · 1269010.1021/ja404757s ↗
19. Mao G. J. · Chem. Commun. · 2014 · 50 · 579010.1039/c4cc01440e ↗
20. Liu C. · Chem. Commun. · 2014 · 50 · 601310.1039/c4cc00980k ↗
21. Yuan L. · Chem.—Eur. J. · 2012 · 18 · 124710.1002/chem.201101434 ↗
22. Wei L. · Sci. Rep. · 2014 · 4 · 452110.1038/srep04521 ↗
23. Spillmann C. M. · Chem. Commun. · 2014 · 50 · 724610.1039/c4cc01072h ↗
24. Zhang H. · Chem. Commun. · 2012 · 48 · 509710.1039/c2cc30422h ↗
25. Albers A. E. · J. Am. Chem. Soc. · 2006 · 128 · 964010.1021/ja063308k ↗
26. Sapsford K. E. · Angew. Chem., Int. Ed. · 2006 · 45 · 4589
27. Lee J. · Chem. Commun. · 2015 · 51 · 87310.1039/C4CC08621J ↗
28. Sen B. · RSC Adv. · 2014 · 4 · 2147110.1039/C4RA02378A ↗
29. Goswami S. · RSC Adv. · 2014 · 4 · 3457210.1039/C4RA05714G ↗
30. Hu Z. · J. Mater. Chem. B · 2014 · 2 · 446710.1039/c4tb00441h ↗
31. Goswami S. · Tetrahedron Lett. · 2014 · 55 · 394610.1016/j.tetlet.2014.05.018 ↗
32. Hu B. · Biosens. Bioelectron. · 2013 · 49 · 49910.1016/j.bios.2013.06.004 ↗
33. Zhu M. · Inorg. Chem. · 2014 · 53 · 1218610.1021/ic502141q ↗
34. Xuan W. · Chem. Commun. · 2013 · 49 · 1047410.1039/c3cc46095a ↗
35. Seneviratne U. · J. Am. Chem. Soc. · 2013 · 135 · 769310.1021/ja401565w ↗
36. Reisz J. A. · Org. Lett. · 2009 · 11 · 271910.1021/ol900914s ↗
37. Reisz J. A. · J. Am. Chem. Soc. · 2011 · 133 · 1167510.1021/ja203652z ↗
38. Sun W. · Chem. Commun. · 2013 · 49 · 389010.1039/c3cc41244j ↗
39. Sun C.-D. · Chem. Commun. · 2011 · 47 · 863810.1039/c1cc12174j ↗