DataVXACS Applied Materials & InterfacesPaper
journal article·2022-02-16Open access

Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference?

Gemma Conte, Gabriella Costabile, Domizia Baldassi, Valeria Rondelli, Rosaria Bassi, Diego Colombo, Giulia Linardos, Ersilia V. Fiscarelli, Raffaella Sorrentino, Agnese Miro, Fabiana Quaglia, Paola Brocca, Ivana d’Angelo, Olivia M. Merkel, Francesca Ungaro

ACS Applied Materials & Interfaces· Volume 14· Issue 6
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Source abstract

Abstract

NFκB gene silencing was achieved in LPS-stimulated 16HBE14o- cells. Overall, the results highlight the potential of non-PEGylated hNPs as carriers for pulmonary delivery of siRNA for local treatment of CF lung disease. Furthermore, this study provides a detailed understanding of how distinct models may provide different information on nanoparticle interaction with the mucus barrier.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Cystic Fibrosis Research Advances · Neonatal Respiratory Health Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Di.S.T.A.Bi.F., University of Campania Luigi Vanvitelli, Caserta 81100, Italy

Department of Pharmacy, University of Napoli Federico II, Napoli 80131, Italy

Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-Universität, München, Munich 81377, Germany

Department of Medical Biotechnologies and Translational Medicine, University of Milano, Segrate (MI) 20090, Italy

Children’s Hospital Bambino Gesù IRCCS, Rome 00165, Italy

Department of Molecular Medicine and Medical Biotechnologies, University of Napoli Federico II, Napoli 80131, Italy

Funding

Ministero dell???Istruzione, dell???Universit?? e della Ricerca · Fondazione per la Ricerca sulla Fibrosi Cistica · Department of Medical Biotechnology and Translational Medicine, University of Milano

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