Translational status of biomedical Mg devices in China
Source abstract
Abstract
Magnesium (Mg) and its alloys as temporary medical implants with biodegradable and properly mechanical properties have been investigated for a long time. There are already three kinds of biodegradable Mg implants which are approved by Conformite Europeene (CE) or Korea Food and Drug Administration (KFDA), but not China Food and Drug Administration (CFDA, now it is National Medical Products Administration, NMPA). As we know, Chinese researchers, surgeons, and entrepreneurs have tried a lot to research and develop biodegradable Mg implants which might become other new approved implants for clinical applications. So in this review, we present the representative Mg implants of three categories, orthopedic implants, surgical implants, and intervention implants and provide an overview of current achievement in China from academic publications and Chinese patents. We would like to provide a systematic way to translate Mg and its alloy implants from experiment designs to clinical products.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Hydrogen Storage and Materials · Aluminum Alloys Composites Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (83)
Show source-provided references
1. A new ligature
2. Preliminary results after application of absorbable metal stents patients with critical limb ischemia10.1583/04-1349R.1 ↗
3. Biodegradable magnesium-based screw clinically equivalent to titanium screw in hallux valgus surgery: short term results of the first prospective, randomized, controlled clinical pilot study10.1186/1475-925X-12-62 ↗
4. Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy10.1073/pnas.1518238113 ↗
5. Development of magnesium alloys for biomedical applications: structure, process to property relationship10.1080/10667857.2017.1405890 ↗
6. Effects of alloying elements on the corrosion behavior and biocompatibility of biodegradable magnesium alloys: a review10.1039/C3TB21746A ↗
7. G. Yuan, X. Zhang, W. Ding. High-toughness Corrosion-Resistant Magnesium Alloy Implanted Material Capable of Being Degraded in Organism: China, CN201010204719.9. 2010-09-22.
8. G. Yuan, Z. Li, J. Niu, X. Zhang, W. Ding. Method for Preparing Bioactive Calcium Phosphate Coating on Magnesium Alloy Surface for Endosseous Implant: China, CN201110086203.3. 2011-04-07.
9. Enhancement of osteogenesis and biodegradation control by brushite coating on Mg–Nd–Zn–Zr alloy for mandibular bone repair10.1021/am506543a ↗
10. The in vivo degradation and bone-implant interface of Mg - Nd - Zn - Zr alloy screws: 18 months post-operation results10.1016/j.corsci.2016.10.009 ↗
11. Mg-based bone implants show promising osteoinductivity and controllable degradation: a long-term study in a goat femoral condyle fracture model10.1016/j.msec.2017.12.014 ↗
12. Influence of surface modifications on the degradation of standard-sized magnesium plates and healing of mandibular osteotomies in miniature pigs
13. Bioabsorbable interbody magnesium-polymer cage10.1097/BRS.0000000000000507 ↗
14. J. Liu, S. Zhang, Y. Zhang, M. Jiang, H. Xu, C. Zhao, X. Zhang. Metal Vascular Clamp Capable of Being Degraded and Absorbed Directionally and Manufacturing Method: China, CN201410156536.2. 2014-07-02.
15. Comparison of SCAphoid fracture osteosynthesis by MAGnesium-based headless Herbert screws with titanium Herbert screws: protocol for the randomized controlled SCAMAG clinical trial
16. Corrosion behavior, biocompatibility and biomechanical stability of a prototype magnesium-based biodegradable intramedullary nailing system10.1016/j.msec.2015.10.006 ↗
17. Magnesium ring device to restore function of a transected anterior cruciate ligament in the goat stifle joint10.1002/jor.23210 ↗
18. S. Zhang, X. Zhang, J. Liu, Y. Zhang, H. Xu, C. Zhao, J. Ni, X. Wang, M. Jiang. Directionally Degradable and Absorbable Magnesium Bone Screw and Preparation Method: China, CN201510496092.1. 2015-11-18.
19. In vivo corrosion of four magnesium alloys and the associated bone response10.1016/j.biomaterials.2004.09.049 ↗
20. Magnesium alloys as a biomaterials for degradable craniofacial screws10.1016/j.actbio.2013.12.040 ↗
21. In vivo study of magnesium plate and screw degradation and bone fracture healing10.1016/j.actbio.2015.02.010 ↗
22. Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone10.1016/j.actbio.2011.11.008 ↗
23. Comparative biomechanical and radiological characterization of osseointegration of a biodegradable magnesium alloy pin and a copolymeric control for osteosynthesis10.1016/j.jmbbm.2013.08.008 ↗
24. Biodegradable magnesium scaffolds: Part 1: appropriate inflammatory response10.1002/jbm.a.31170 ↗
25. Biodegradable magnesium scaffolds: Part II: peri-implant bone remodeling10.1002/jbm.a.31293 ↗
26. Magnesium and its alloys as orthopedic biomaterials: a review10.1016/j.biomaterials.2005.10.003 ↗
27. Intermediate analysis of magnesium alloy covered stent for a lateral aneurysm model in the rabbit common carotid artery10.1007/s00330-016-4715-6 ↗
28. Site-dependent osseointegration of biodegradable high-purity magnesium for orthopedic implants in femoral shaft and femoral condyle of New Zealand rabbits10.1016/j.jmst.2016.03.012 ↗
29. Loss of mechanical properties in vivo and bone–implant interface strength of AZ31B magnesium alloy screws with Si-containing coating10.1016/j.actbio.2013.12.020 ↗
30. In vitro and in vivo studies on the degradation of high-purity Mg (99.99 wt.%) screw with femoral intracondylar fractured rabbit model10.1016/j.biomaterials.2015.06.031 ↗
31. Magnesium alloy based interference screw developed for ACL reconstruction attenuates peri-tunnel bone loss in rabbits10.1016/j.biomaterials.2017.12.007 ↗
32. Magnesium inference screw supports early graft incorporation with inhibition of graft degradation in anterior cruciate ligament reconstruction
33. High-purity magnesium interference screws promote fibrocartilaginous entheses regeneration in the anterior cruciate ligament reconstruction rabbit model via accumulation of BMP-2 and VEGF10.1016/j.biomaterials.2015.12.005 ↗
34. Biodegradable magnesium screws accelerate fibrous tissue mineralization at the tendon-bone insertion in anterior cruciate ligament reconstruction model of rabbit
35. Magnesium (Mg) based interference screws developed for promoting tendon graft incorporation in bone tunnel in rabbits10.1016/j.actbio.2017.09.018 ↗
36. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head10.1016/j.biomaterials.2015.11.038 ↗
37. CFDA
38. NetEase News
39. Biodegradable magnesium screws and vascularized iliac grafting for displaced femoral neck fracture in young adults
40. Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits10.1016/j.biomaterials.2015.04.038 ↗
41. Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits10.1016/j.biomaterials.2017.10.025 ↗
42. Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect10.1016/j.biomaterials.2019.01.013 ↗
43. Special biodegradable fixation device for anterior cruciate ligament reconstruction–safety and efficacy in a beagle model10.1021/acsbiomaterials.8b00426 ↗
44. An innovative Mg/Ti hybrid fixation system developed for fracture fixation and healing enhancement at load-bearing skeletal site10.1016/j.biomaterials.2018.07.018 ↗
45. Accelerating corrosion of pure magnesium co-implanted with titanium in vivo
46. G. Yuan, Z. Ruan, H. Shi. Biodegradable Magnesium Alloy Claw Type Rib Coaptation Board: China, CN201520145649.2. 2015-03-13.
47. J. Niu, J. Zhang, G. Yuan, W. Ding, D. Dong, Q. Shen. Magnesium Alloy Sternum Plate: China, CN201810522821.X. 2018-11-06.
48. D. Zhao, B. Wang, H. Xie, B. Liu, Z. Ma, W. Wang. A T-Type/inclined T-type Degradable Pure Magnesium Distal Radius Bone Plate: China, CN201710906845.0. 2017-12-12.
49. D. Zhao, B. Wang, H. Xie, B. Liu, Z. Ma, W. Wang. Degradable Pure Magnesium Metal Bone Fracture Plate for Limb Long Bone Fracture Fixation: China, CN201710908933.4. 2017-12-22.
50. CFDA
51. Fabrication, microstructure, and properties of a biodegradable Mg‐Zn‐Ca clip10.1002/jbm.b.34267 ↗
52. Biodegradable metallic wires in dental and orthopedic applications: a review
53. A study of magnesium wire as an absorbable suture and ligature material10.1001/archsurg.1924.01120050210011 ↗
54. Preparation, microstructure and degradation performance of biomedical magnesium alloy fine wires10.1016/j.pnsc.2014.08.015 ↗
55. Research of a novel biodegradable surgical staple made of high purity magnesium10.1016/j.bioactmat.2016.09.005 ↗
56. In vivo and in vitro assessment of the biocompatibility and degradation of high-purity Mg anastomotic staples10.1177/0885328217692948 ↗
57. In vivo evaluation of Mg–6Zn and titanium alloys on collagen metabolism in the healing of intestinal anastomosis
58. High-Purity magnesium staples suppress inflammatory response in rectal anastomoses10.1021/acsami.7b00813 ↗
59. A novel biodegradable Mg–Nd–Zn–Zr alloy with uniform corrosion behavior in artificial plasma10.1016/j.matlet.2012.08.012 ↗
60. The microstructure and properties of cyclic extrusion compression treated Mg–Zn–Y–Nd alloy for vascular stent application10.1016/j.jmbbm.2011.12.011 ↗
61. Processing and properties of magnesium alloy micro-tubes for biodegradable vascular stents10.1016/j.msec.2018.05.005 ↗
62. Effectiveness of biodegradable magnesium alloy stents in coronary artery and femoral artery10.1111/joic.12217 ↗
63. Biodegradable magnesium alloy stents as a treatment for vein graft restenosis10.3349/ymj.2019.60.5.429 ↗
64. Enhanced performance of magnesium alloy for drug-eluting vascular scaffold application10.1016/j.apsusc.2017.11.090 ↗
65. The degradation and transport mechanism of a Mg - Nd - Zn - Zr stent in rabbit common carotid artery: a 20-month study10.1016/j.actbio.2018.01.018 ↗
66. A surface-eroding poly(1,3-trimethylene carbonate) coating for fully biodegradable magnesium-based stent applications: toward better biofunction, biodegradation and biocompatibility10.1016/j.actbio.2013.02.041 ↗
67. Enhanced bioactivity of Mg–Nd–Zn–Zr alloy achieved with nanoscale MgF2 surface for vascular stent application10.1021/am5086885 ↗
68. The processing of Mg alloy micro-tubes for biodegradable vascular stents10.1016/j.msec.2014.12.024 ↗
69. Nanophasic biodegradation enhances the durability and biocompatibility of magnesium alloys for the next-generation vascular stents10.1039/c3nr02912c ↗
70. In vivo response of AZ31 alloy as biliary stents: a 6 months evaluation in rabbits
71. Technical feasibility and tissue reaction after silicone-covered biodegradable magnesium stent insertion in the oesophagus: a primary study in vitro and in vivo10.1007/s00330-016-4602-1 ↗
72. In vitro and in vivo corrosion measurements of Mg–6Zn alloys in the bile10.1016/j.msec.2014.05.014 ↗
73. Biodegradable intestinal stents: a review10.1016/j.pnsc.2014.08.008 ↗
74. The current status of biodegradable stent to treat benign luminal disease10.1016/j.mattod.2017.05.002 ↗
75. In vitro degradation of pure Mg for esophageal stent in artificial saliva10.1016/j.jmst.2016.02.007 ↗
76. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats10.1038/nm.4162 ↗
77. An in situ depot for continuous evolution of gaseous H2 mediated by a magnesium passivation/activation cycle for treating osteoarthritis10.1002/anie.201806159 ↗
78. Magnesium metal - a potential biomaterial with antibone cancer properties10.1002/jbm.a.34933 ↗
79. On the antitumor properties of biomedical magnesium metal10.1039/C4TB01421A ↗
80. Influence of stress on the degradation behavior of Mg LAE442 implant systems10.1016/j.procir.2013.01.038 ↗
81. Crevice corrosion - a newly observed mechanism of degradation in biomedical magnesium10.1016/j.actbio.2019.06.013 ↗
82. A review on the exploitation of biodegradable magnesium-based composites for medical applications10.1088/1748-605X/aa8fa0 ↗
83. Surface modifications of magnesium alloys for biomedical applications10.1007/s10439-011-0300-y ↗