Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application
Source abstract
Abstract
In this work, Ti-Mg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to Ti-Mg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was employed, and Ti-Mg MMCs implants were embedded into the femur condyles. Results showed that Ti-Mg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti. The micro-computed tomography (Micro-CT) results showed that the volume of bone trabecula was significantly more abundant around Ti-Mg implants than around Ti implants, indicating that more active new-bone formed around Ti-Mg MMCs implants. Hematoxylin-eosin (H&E) staining analysis revealed significantly greater osteointegration around Ti-Mg implants than that around Ti implants.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Orthopaedic implants and arthroplasty · Titanium Alloys Microstructure and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (24)
Show source-provided references
1. Ti based biomaterials, the ultimate choice for orthopaedic implants – a review10.1016/j.pmatsci.2008.06.004 ↗
2. Advances in metals and alloys for joint replacement10.1016/j.pmatsci.2017.04.002 ↗
3. Titanium alloys
4. Enhanced osteointegration of medical titanium implant with surface modifications in micro/nanoscale structures10.1016/j.jot.2013.08.001 ↗
5. In vitro biocompatibility evaluation of surface-modified titanium alloys10.1002/jbm.a.32507 ↗
6. Covalently immobilised type I collagen facilitates osteoconduction and osseointegration of titanium coated implants10.1016/j.jot.2015.08.005 ↗
7. Biodegradable metals10.1016/j.mser.2014.01.001 ↗
8. Design of magnesium alloys with controllable degradation for biomedical implants: from bulk to surface10.1016/j.actbio.2016.09.005 ↗
9. Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone10.1016/j.actbio.2011.11.008 ↗
10. Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models
11. In vitro and in vivo corrosion and histocompatibility of pure Mg and a Mg-6Zn alloy as urinary implants in rat model10.1016/j.msec.2016.06.017 ↗
12. Novel magnesium alloys developed for biomedical application_ a review10.1016/j.jmst.2013.02.005 ↗
13. Review of titanium surface modification techniques and coatings for antibacterial applications
14. Titanium–magnesium based composites: mechanical properties and in-vitro corrosion response in Ringer's solution10.1016/j.msea.2013.02.040 ↗
15. Study on titanium-magnesium composites with bicontinuous structure fabricated by powder metallurgy and ultrasonic infiltration10.1016/j.jmbbm.2018.02.017 ↗
16. Powder metallurgical low-modulus Ti–Mg alloys for biomedical applications10.1016/j.msec.2015.06.010 ↗
17. Size effect of B4C powders on metallurgical reaction and resulting tensile properties of Ti matrix composites by in-situ reaction from Ti–B4C system under a relatively low temperature10.1016/j.msea.2014.07.020 ↗
18. Metal matrix to ceramic matrix transition via feedstock processing of SPS titanium composites alloyed with high silicone content10.1016/j.jallcom.2018.06.086 ↗
19. Design of magnesium alloys with controllable degradation for biomedical implants: from bulk to surface10.1016/j.actbio.2016.09.005 ↗
20. Study on titanium-magnesium composites with bicontinuous structure fabricated by powder metallurgy and ultrasonic infiltration10.1016/j.jmbbm.2018.02.017 ↗
21. Surface-dimpled commercially pure titanium implant and bone ingrowth10.1016/S0142-9612(96)00185-8 ↗
22. Effect of surface finish on the osseointegration of laser-treated titanium alloy implants10.1016/j.biomaterials.2003.11.002 ↗
23. Fabrication and characterization of porous Ti–10Cu alloy for biomedical application10.1016/j.jallcom.2017.06.321 ↗
24. Enhanced SaOS-2 cell adhesion, proliferation and differentiation on Mg-incorporated micro/nano-topographical TiO 2 coatings10.1016/j.apsusc.2018.04.095 ↗