Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis
Source abstract
Abstract
The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge. The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation. Herein, we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen (PCEI) and multifunctional PCEI-based F127-ε-polypeptide-alginic (FEA) dressing (FEA-PCEI) for accelerating wound healing and hair follicle neogenesis. PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization. The FEA-PCEI dressing showed the temperature-response gelation, injectability, robust antibacterial activity, light-damage-resistant, homeostasis ability, and good cytocompatibility. The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability, reduce the scar formation, and promote the hair follicle neogenesis. This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Surgical Sutures and Adhesives · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (33)
Show source-provided references
1. Human skin wounds: a major and snowballing threat to public health and the economy10.1111/j.1524-475X.2009.00543.x ↗
2. Diabetes and wound angiogenesis
3. Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms10.1016/j.addr.2018.03.012 ↗
4. Silencing tnfα with lipidoid nanoparticles downregulates both tnfα and mcp-1 in an in vitro co-culture model of diabetic foot ulcers10.1016/j.actbio.2015.12.023 ↗
5. Macrophage activation and polarization: Nomenclature and experimental guidelines10.1016/j.immuni.2014.06.008 ↗
6. Exacerbated and prolonged inflammation impairs wound healing and increases scarring10.1111/wrr.12381 ↗
7. Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis10.1056/NEJMoa1611593 ↗
8. Metabolomics approach for validation of self-reported ibuprofen and acetaminophen use
9. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release10.1021/acs.chemrev.5b00346 ↗
10. Antibacterial effects and ibuprofen release potential using chitosan microspheres loaded with silver nanoparticles
11. Topical antimicrobial therapy for treating chronic wounds10.1086/644732 ↗
12. A comparison of postprocedural wound care treatments: Do antibiotic-based ointments improve outcomes?10.1016/j.jaad.2010.11.010 ↗
13. A biomimetic mussel‐inspired ε‐poly‐l‐lysine hydrogel with robust tissue‐anchor and anti‐infection capacity
14. Bioactive anti-inflammatory, antibacterial, antioxidative silicon-based nanofibrous dressing enables cutaneous tumor photothermo-chemo therapy and infection-induced wound healing10.1021/acsnano.9b07173 ↗
15. Antimicrobial action of epsilon-poly-l-lysine
16. Agents that increase the permeability of the outer membrane
17. Antibacterial activity and mechanism of action of epsilon-poly-l-lysine10.1016/j.bbrc.2013.08.001 ↗
18. Efficient angiogenesis-based diabetic wound healing/skin reconstruction through bioactive antibacterial adhesive ultraviolet shielding nanodressing with exosome release10.1021/acsnano.9b03656 ↗
19. A dual network hydrogel sunscreen based on poly-γ-glutamic acid/tannic acid demonstrates excellent anti-uv, self-recovery, and skin-integration capacities10.1021/acsami.9b14538 ↗
20. Self-adapting hydrogel to improve the therapeutic effect in wound-healing10.1021/acsami.8b08874 ↗
21. Novel citric acid〣ased biodegradable elastomers for tissue engineering10.1002/adma.200306264 ↗
22. Guo · 2016 · 204
23. Biomimetic bioactive multifunctional poly(citrate-siloxane)-based nanofibrous scaffolds enable efficient multidrug-resistant bacterial treatment/non-invasive tracking in vitro/in vivo
24. Wang · 2020
25. Bioactive biodegradable polycitrate nanoclusters enhances the myoblast differentiation and in vivo skeletal muscle regeneration via p38 mapk signaling pathway
26. Biomimetic elastomeric bioactive siloxane‐based hybrid nanofibrous scaffolds with mirna activation: a joint physico‐chemical‐biological strategy for promoting bone regeneration
27. Conformational stability of ibuprofen: Assessed by dft calculations and optical vibrational spectroscopy
28. Inflammation in wound repair: molecular and cellular mechanisms10.1038/sj.jid.5700701 ↗
29. Exacerbated and prolonged inflammation impairs wound healing and increases scarring10.1111/wrr.12381 ↗
30. Ibuprofen attenuates cardiac fibrosis in streptozotocin-induced diabetic rats10.1159/000375362 ↗
31. Sirna-targeting transforming growth factor-β type i receptor reduces wound scarring and extracellular matrix deposition of scar tissue10.1038/jid.2014.84 ↗
32. Antibacterial hydrogels10.1002/advs.201700527 ↗
33. A novel uv-shielding and transparent polymer film: when bioinspired dopamine–melanin hollow nanoparticles join polymers10.1021/acsami.7b08763 ↗