DataVXACS Applied Materials & InterfacesPaper
journal article·2020-03-18

Macroporous Hydrogel Scaffolds with Tunable Physicochemical Properties for Tissue Engineering Constructed Using Renewable Polysaccharides

Xiaoliang Qi, Ting Su, Mengying Zhang, Xianqin Tong, Wenhao Pan, Qiankun Zeng, Zaigang Zhou, Liangliang Shen, Xiaojun He, Jianliang Shen

ACS Applied Materials & Interfaces· Volume 12· Issue 11
Publisher page
Source abstract

Abstract

Polysaccharides have recently attracted increasing attention in the construction of hydrogel devices for biomedical applications. However, polysaccharide-based hydrogels are not suitable for most preclinical applications because of their limited mechanical properties and poor tunability. In this study, we employed a simple and eco-friendly approach to producing a macroporous polysaccharide hydrogel composed of salecan and κ-carrageenan without the use of toxic chemicals. We evaluated the physicochemical properties of the obtained salecan/κ-carrageenan hydrogel and found that its viscoelasticity, morphology, swelling, and thermal stability could be simply controlled by changing the polysaccharide dose in the pre-gel solution. The co-incubation of the fabricated hydrogel with mouse fibroblast cells demonstrated that the hydrogel can support cell adhesion, migration, and growth. Moreover, the hydrogel exhibited good biocompatibility in vivo. Overall, the findings provide a new strategy for the fabrication and optimization of polysaccharide-based hydrogel scaffolds for application in tissue engineering.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersBiomaterials

OpenAlex topics: Hydrogels: synthesis, properties, applications · Electrospun Nanofibers in Biomedical Applications · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Xueyuan West Road, Lucheng District, Wenzhou 325027, China

Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Xinsan Road, Longwan District, Wenzhou 325001, China

Department of Orthodontics, School & Hospital of Stomatology, Wenzhou Medical University, Xueyuan West Road, Lucheng District, Wenzhou 325027, China

Funding

Wenzhou Medical University · National Health and Family Planning Commission of the People's Republic of China · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province · Wenzhou Science and Technology Plan Project · Wenzhou Institute of Biomaterials and Engineering

References (42)

Show source-provided references
1. 10.1016/j.carbpol.2019.11521010.1016/j.carbpol.2019.115210 ↗
2. 10.1007/s10570-019-02490-110.1007/s10570-019-02490-1 ↗
3. 10.1016/j.jconrel.2012.11.00510.1016/j.jconrel.2012.11.005 ↗
4. 10.1021/acsami.6b0226410.1021/acsami.6b02264 ↗
5. 10.1016/j.ijbiomac.2016.12.07110.1016/j.ijbiomac.2016.12.071 ↗
6. 10.1021/ie301254z10.1021/ie301254z ↗
7. 10.1016/j.cej.2018.07.12610.1016/j.cej.2018.07.126 ↗
8. 10.1021/acs.biomac.8b0082410.1021/acs.biomac.8b00824 ↗
9. 10.1016/j.jconrel.2015.10.03510.1016/j.jconrel.2015.10.035 ↗
10. 10.1016/j.cej.2018.10.09010.1016/j.cej.2018.10.090 ↗
11. 10.1016/j.msec.2019.11005010.1016/j.msec.2019.110050 ↗
12. 10.1039/C8TB03020K10.1039/C8TB03020K ↗
13. 10.1016/j.jhazmat.2019.12098010.1016/j.jhazmat.2019.120980 ↗
14. 10.1007/s10570-017-1249-210.1007/s10570-017-1249-2 ↗
15. 10.1517/17425247.2014.89732610.1517/17425247.2014.897326 ↗
16. 10.1021/ie302581m10.1021/ie302581m ↗
17. 10.1021/acs.biomac.5b0064010.1021/acs.biomac.5b00640 ↗
18. 10.1016/j.jcis.2019.02.02510.1016/j.jcis.2019.02.025 ↗
19. 10.1016/j.carres.2015.09.00210.1016/j.carres.2015.09.002 ↗
20. 10.1016/j.carbpol.2014.05.08510.1016/j.carbpol.2014.05.085 ↗
21. 10.1016/j.carbpol.2017.07.03910.1016/j.carbpol.2017.07.039 ↗
22. 10.1039/C8TB03312A10.1039/C8TB03312A ↗
23. 10.1021/acssuschemeng.9b0213910.1021/acssuschemeng.9b02139 ↗
24. 10.1016/j.carbpol.2017.08.13310.1016/j.carbpol.2017.08.133 ↗
25. 10.1021/acs.jafc.8b0287910.1021/acs.jafc.8b02879 ↗
26. 10.1021/acsbiomaterials.6b0031810.1021/acsbiomaterials.6b00318 ↗
27. 10.1016/j.actbio.2014.09.01810.1016/j.actbio.2014.09.018 ↗
28. 10.1016/j.cej.2017.08.00410.1016/j.cej.2017.08.004 ↗
29. 10.1021/acsbiomaterials.6b0067010.1021/acsbiomaterials.6b00670 ↗
30. 10.1039/C5TB00264H10.1039/C5TB00264H ↗
31. 10.1016/j.carbpol.2019.11520810.1016/j.carbpol.2019.115208 ↗
32. 10.1016/j.foodhyd.2018.12.05610.1016/j.foodhyd.2018.12.056 ↗
33. 10.1021/acssuschemeng.9b0218610.1021/acssuschemeng.9b02186 ↗
34. 10.1021/acs.molpharmaceut.6b0087510.1021/acs.molpharmaceut.6b00875 ↗
35. 10.1016/j.carbpol.2019.01.01510.1016/j.carbpol.2019.01.015 ↗
36. 10.1016/j.carbpol.2017.10.08810.1016/j.carbpol.2017.10.088 ↗
37. 10.1021/acs.biomac.7b0172410.1021/acs.biomac.7b01724 ↗
38. 10.1002/adfm.20180785810.1002/adfm.201807858 ↗
39. 10.1038/s41565-018-0097-z10.1038/s41565-018-0097-z ↗
40. 10.1002/mabi.20170036910.1002/mabi.201700369 ↗
41. 10.1016/j.carbpol.2013.01.08410.1016/j.carbpol.2013.01.084 ↗
42. 10.1016/j.colsurfb.2019.03.05010.1016/j.colsurfb.2019.03.050 ↗