Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration
Source abstract
Abstract
Prevention of recurrence/metastasis and tissue regeneration are critical for post-surgery treatment of malignant tumors. Here, to address these needs, a novel type of microgel co-loading cryo-shocked cancer cells, immunoadjuvant, and immune checkpoint inhibitor is presented by microfluidic electrospray technology and liquid nitrogen treatment. Owing to the encapsulation of cryo-shocked cancer cells and immunoadjuvant, the microgels can recruit dendritic cells and activate them in situ, and evoke a robust immune response. Moreover, with the combination of the immune checkpoint inhibitor, the antitumor immune response is further enhanced by inhibiting the interaction of PD1 and PDL1. With this, the excellent anti-recurrence and anti-metastasis efficacy of the microgels are demonstrated in an orthotopic breast cancer mouse model. Besides, because of the excellent biocompatibility and appropriate degradation performance, the microgels can provide support for normal cell adhesion and growth, which is beneficial to tissue reconstruction. These properties indicate the great value of the cryo-shocked cancer cell microgels for efficient tumor postoperative combination immunotherapy and tissue regeneration.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Nanoplatforms for cancer theranostics · Electrohydrodynamics and Fluid Dynamics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (46)
Show source-provided references
1. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2. Sandwich-like fibers/sponge composite combining chemotherapy and hemostasis for efficient postoperative prevention of tumor recurrence and metastasis10.1002/adma.201803217 ↗
3. Germanene-based theranostic materials for surgical adjuvant treatment: inhibiting tumor recurrence and wound infection10.1016/j.matt.2020.04.022 ↗
4. Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy10.1007/s12274-020-3066-4 ↗
5. Near-infrared light-triggered polyprodrug/siRNA loaded upconversion nanoparticles for multi-modality imaging and synergistic cancer therapy10.1002/adhm.202100938 ↗
6. Photoactivatable prodrug-backboned polymeric nanoparticles for efficient light-controlled gene delivery and synergistic treatment of platinum-resistant ovarian cancer10.1021/acs.nanolett.9b04981 ↗
7. Photoactivated polyprodrug nanoparticles for effective light-controlled Pt(iv) and siRNA codelivery to achieve synergistic cancer therapy10.1039/D0TB01103G ↗
8. Morphology tunable and acid-sensitive dextran-doxorubicin conjugate assemblies for targeted cancer therapy10.1039/D0TB00746C ↗
9. Engineered nanoparticles for drug delivery in cancer therapy10.1002/anie.201403036 ↗
10. Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy
11. Cancer immunotherapy: harnessing the immune system to battle cancer10.1172/JCI83871 ↗
12. Biopolymer implants enhance the efficacy of adoptive T-cell therapy10.1038/nbt.3104 ↗
13. Engineering dendritic-cell-based vaccines and PD-1 blockade in self-assembled peptide nanofibrous hydrogel to amplify antitumor T-cell immunity10.1021/acs.nanolett.8b01406 ↗
14. Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors10.1038/s41467-020-19540-z ↗
15. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment10.1038/s41565-018-0319-4 ↗
16. Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy, Bioact
17. Synthetic immune niches for cancer immunotherapy10.1038/nri.2017.89 ↗
18. Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy10.1016/j.cej.2022.140619 ↗
19. Microfluidic spinning of micro- and nano-scale fibers for tissue engineering10.1039/C3LC51414E ↗
20. Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged nanobullets10.1021/acsnano.0c07721 ↗
21. 3D printing of hydrogel scaffolds for future application in photothermal therapy of breast cancer and tissue repair10.1016/j.actbio.2019.05.039 ↗
22. Photopolymerized 3D printing scaffolds with Pt(IV) prodrug initiator for postsurgical tumor treatment10.34133/2022/9784510 ↗
23. Cryo-shocked cancer cells for targeted drug delivery and vaccination10.1126/sciadv.abc3013 ↗
24. Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns10.1038/s41551-021-00795-w ↗
25. Thriving microfluidic technology10.1016/j.scib.2020.07.030 ↗
26. Interplay between materials and microfluidics
27. Current developments and applications of microfluidic technology toward clinical translation of nanomedicines10.1016/j.addr.2017.08.003 ↗
28. Injectable microfluidic hydrogel microspheres for cell and drug delivery
29. Hierarchical microparticles delivering oxaliplatin and NLG919 nanoprodrugs for local chemo-immunotherapy10.1021/acsami.2c16564 ↗
30. Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer cells10.1016/j.addr.2011.05.007 ↗
31. Microfluidics-assisted engineering of polymeric microcapsules with high encapsulation efficiency for protein drug delivery10.1016/j.ijpharm.2014.06.012 ↗
32. Microfluidic-assisted fabrication of carriers for controlled drug delivery10.1039/C7LC00242D ↗
33. Hydrogel microparticles for biomedical applications10.1038/s41578-019-0148-6 ↗
34. Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels
35. Capturing magnesium ions via microfluidic hydrogel microspheres for promoting cancellous bone regeneration10.1021/acsnano.1c02147 ↗
36. Stem cell-recruiting injectable microgels for repairing osteoarthritis
37. Injectable stem cell-laden photocrosslinkable microspheres fabricated using microfluidics for rapid generation of osteogenic tissue constructs10.1002/adfm.201504943 ↗
38. In-air production of 3D co-culture tumor spheroid hydrogels for expedited drug screening10.1016/j.actbio.2019.06.012 ↗
39. Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
40. Immunotherapeutic uses of CpG oligodeoxynucleotides10.1038/nri1329 ↗
41. Infection-mimicking materials to program dendritic cells in situ10.1038/nmat2357 ↗
42. Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma10.1016/j.biomaterials.2018.01.004 ↗
43. A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy10.1016/j.biomaterials.2020.119960 ↗
44. An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration10.1039/C8MH00704G ↗
45. Degradable porous drug-loaded polymer scaffolds for localized cancer drug delivery and breast cell/tissue growth10.1016/j.msec.2020.110794 ↗
46. Photothermal hydrogel platform for prevention of post-surgical tumor recurrence and improving breast reconstruction10.1186/s12951-021-01041-w ↗