Bioceramics Composed of Octacalcium Phosphate Demonstrate Enhanced Biological Behavior
Source abstract
Abstract
Bioceramics are used to treat bone defects but in general do not induce formation of new bone, which is essential for regeneration process. Many aspects related to bioceramics synthesis, properties and biological response that are still unknown and, there is a great need for further development. In the most recent research efforts were aimed on creation of materials from biological precursors of apatite formation in humans. One possible precursor is octacalcium phosphate (OCP), which is believed to not only exhibit osteoconductivity but possess osteoinductive quality, the ability to induce bone formation. Here we propose a relatively simple route for OCP ceramics preparation with a specifically designed microstructure. Comprehensive study for OCP ceramics including biodegradation, osteogenic properties in ortopic and heterotopic models and limited clinical trials were performed that demonstrated enhanced biological behavior. Our results provide a possible new concept for the clinical applications of OCP ceramics.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Endodontics and Root Canal Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia
BioNova LLC, Moscow, Russia
Human Stem Cells Institute, Moscow, Russia
State Research Centre−Burnasyan Federal Medical Biophysical Centre, Federal Medical Biological Agency of Russia, Moscow, Russia
Central Scientific Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia
I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Moscow, Russia
P.A. Hertzen Moscow Oncology Research Institute, Moscow, Russia
National Hematology Research Centre, Moscow, Russia
Funding
Russian Foundation for Basic Research · Russian Foundation for Assistance to Small Innovative Enterprises in Science and Technology
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