journal article·2014-06-25

Cell Membrane Tracker Based on Restriction of Intramolecular Rotation

Chunqiu Zhang, Shubin Jin, Keni Yang, Xiangdong Xue, Zhipeng Li, Yonggang Jiang, Wei-Qiang Chen, Luru Dai, Guozhang Zou, Xing-Jie Liang

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Abstract

The fluorescence of tetraphenylethylene (TPE), an archetypal luminogen, is induced by restriction of intramolecular rotation (RIR). TPE was grafted with palmitic acid (PA) onto a hydrophilic peptide to yield a cell membrane tracker named TR4. TR4 was incorporated into liposomes, where it showed significant RIR characteristics. When cells were incubated with TR4, cytoplasmic membranes were specifically labeled. TR4 shows excellent photostability and low cytotoxicity.
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Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Molecular Sensors and Ion Detection · Photoreceptor and optogenetics research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China

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