DataVXACS Applied Materials & InterfacesPaper
journal article·2017-09-06Open access

An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

Onur Bas, Davide D’Angella, Jeremy G. Baldwin, Nathan J. Castro, Felix M. Wunner, Navid T. Saidy, Stefan Kollmannsberger, Alessandro Reali, Ernst Rank, Elena M. De-Juan-Pardo, Dietmar W. Hutmacher

ACS Applied Materials & Interfaces· Volume 9· Issue 35
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Source abstract

Abstract

We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger ( E = 3.19 MPa) and ∼100 times tougher ( W Ext = ∼2000 kJ m –3 ) than its hydrogel counterpart.
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Research context

PolymersBiomaterialsComposites

OpenAlex topics: 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute for Advanced Study, Technische Universität München, Lichtenbergstraße 2 a, 85748 Garching, Germany

Chair for Computation in Engineering, Technische Universität München, D-80333 Munich, Germany

Department of Civil Engineering and Architecture, University of Pavia, via Ferrata 3, 27100 Pavia, Italy

Funding

National Breast Cancer Foundation · Worldwide Cancer Research · National Health and Medical Research Council · Deutsche Forschungsgemeinschaft · Australian Research Council · Seventh Framework Programme

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