DataVXACS Applied Materials & InterfacesPaper
journal article·2018-04-04

Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations

Xiaodong Zhang, Xiaokai Chen, Yao-Wen Jiang, Ningning Ma, Liu-Yuan Xia, Xiaotong Cheng, Hao-Ran Jia, Peidang Liu, Ning Gu, Zhan Chen, Fu-Gen Wu

ACS Applied Materials & Interfaces· Volume 10· Issue 13
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Source abstract

Abstract

The therapeutic performance of cancer radiotherapy is often limited by the overexpression of glutathione (GSH) in tumors and low radiation sensitivity of cancerous cells. To address these issues, the facilely prepared histidine-capped gold nanoclusters (Au NCs@His) were adopted as a radiosensitizer with a high sensitization enhancement ratio of ∼1.54. On one hand, Au NCs@His can inherit the local radiation enhancement property of gold-based materials (external regulation); on the other hand, Au NCs@His can decrease the intracellular GSH level, thus preventing the generated reactive oxygen species (ROS) from being consumed by GSH, and arrest the cells at the radiosensitive G2/M phase (internal regulation).
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanocluster Synthesis and Applications · Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

School of Medicine, Southeast University, Nanjing 210009, China

Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States

Funding

University of Michigan · Ministry of Education of the People's Republic of China · Natural Science Foundation of Jiangsu Province · Government of Jiangsu Province · National Natural Science Foundation of China · Scientific Research Foundation, Southeast University

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