DataVXACS Applied Materials & InterfacesPaper
journal article·2018-05-02

CaZnOS:Nd3+ Emits Tissue-Penetrating near-Infrared Light upon Force Loading

Lejing Li, Lothar Wondraczek, Lihua Li, Yu Zhang, Ye Zhu, Mingying Peng, Chuanbin Mao

ACS Applied Materials & Interfaces· Volume 10· Issue 17
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Source abstract

Abstract

Mechanoluminescent (ML) materials are mechano-optical converters that can emit light under an external mechanical stimulus. All the existing ML materials can only emit light from near ultraviolet to red, which is outside the near-infrared (NIR) windows desired for biomechanical imaging. No studies have been done on doping rare earth (RE) ions with photoluminescence (PL) in the NIR region into a compound to form a ML material that emits NIR light in response to an external force. Here, we show that doping RE ions with a NIR PL into an inorganic compound does not usually result in the formation of a NIR ML material, which can only be achieved in the combination of Nd3+ ions and a CaZnOS compound among the combinations we studied. The newly discovered NIR ML material (CaZnOS:Nd3+) is biocompatible and can efficiently convert mechanical stress into NIR light over the first and second tissue-penetrating bioimaging window. Its NIR ML emission appeared at a very low force threshold (even when the material was shaken slightly), increased sensitively and linearly with the increase in the force (up to >5 kN), and could penetrate the tissue as deep as >22 mm to enable biomechanical detection. Such a force-responsive behavior is highly reproducible. Hence, CaZnOS:Nd3+ is a new potential ultrasensitive biomechanical probe and expands the ML application horizons into in vivo bioimaging.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Luminescence Properties of Advanced Materials · Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The China-Germany Research Center for Photonic Materials and Devices, The State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Materials Science and Technology, South China University of Technology, Guangzhou 510640, P. R. China

Otto Schott Institute of Materials Research, University of Jena, Jena 07743, Germany

Guangdong Key Lab of Orthopedic Technology and Implant, Department of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, P. R. China

Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States

School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, P. R. China

Funding

National Cancer Center · Ministry of Science and Technology of the People's Republic of China · Ministry of Education of the People's Republic of China · Government of Guangdong Province · Guangzhou Science and Technology Program key projects · National Natural Science Foundation of China

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