journal article·2018-12-12

Integrating 3D Printing and Biomimetic Mineralization for Personalized Enhanced Osteogenesis, Angiogenesis, and Osteointegration

Limin Ma, Xiaolan Wang, Naru Zhao, Ye Zhu, Zhiye Qiu, Qingtao Li, Ye Zhou, Zefeng Lin, Xiang Li, Xiaolong Zeng, Hong Xia, Shizhen Zhong, Yu Zhang, Yingjun Wang, Chuanbin Mao

ACS Applied Materials & Interfaces· Volume 10· Issue 49
Publisher page

Abstract

Titanium (Ti) alloy implants can repair bone defects at load-bearing sites. However, they mechanically mismatch with the natural bone and lack customized adaption with the irregularly major-sized load-bearing bone defects, resulting in the failure of implant fixation. Mineralized collagen (MC), a building block in bone, can induce angiogenesis and osteogenesis, and 3D printing technology can be employed to prepare scaffolds with an overall shape customized to the bone defect. Hence, we induced the formation of MC, made of hydroxyapatite (HAp) nanocrystals and collagen fibers, in 3D-printed porous Ti6Al4V (PT) scaffolds through in situ biomimetic mineralization. The resultant MC/PT scaffolds exhibited a bone-like Young’s modulus and were customized to the anatomical contour of actual bone defects of rabbit model. We found that the biocompatibility and osteogenic differentiation are best when the mass ratio between HAp nanocrystals and collagen fibers is 1 in MC. We then implanted the MC/PT scaffolds into the customized radius defect rabbit model and found that the MC/PT scaffolds significantly improved the vascularized bone tissue formation and integration between new bone and the implants. Therefore, a combination of 3D printing and biomimetic mineralization could lead to customized 3D PT scaffolds for enhanced angiogenesis, osteogenesis, and osteointegration. Such scaffolds represent novel patient-specific implants for precisely repairing irregular major-sized load-bearing bone defects.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Titanium Alloys Microstructure and Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedics, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080,PR China

School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China

Department of Orthopedics, Guangdong Key Lab of Orthopedic Technology and Implant, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010, PR China

Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, Norman, Oklahoma 73072, United States

Institute for Regenerative Medicine and Biomimetic Materials, Tsinghua University, Beijing 100084, PR China

School of Mechanical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Mechanical System and Vibration, Shanghai 200240, PR China

School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China

School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, PR China

Funding

Ministry of Science and Technology of the People's Republic of China · National Institute of Biomedical Imaging and Bioengineering · National Natural Science Foundation of China · Guangzhou Municipality · Military Logistic Science Research Project

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