journal article·2020-05Open access

Microwave assisted synthesis of imidazolyl fluorescent dyes as antimicrobial agents

Chinna Bathula, Ravindra MK, Ashok Kumar K, Hemraj Yadav, Sivalingam Ramesh, Surendra Shinde, Nabeen K Shrestha, Mahadevan KM, Veeranjaneya Reddy, Arifullah Mohammed

Abstract

In this article, we report, the synthesis and characterization of series of novel fluorescent imidazolyl dyes (5a-d) via highly efficient and cost-effective microwave assisted protocol as a potential candidate to overcome the problem of microbial resistance. By utilizing the green microwave protocol the reactions are completed in a short span of time without using the harsh conditions. The incorporation of imidazole nucleus is an important strategy in drug discovery. While designing desired fluorescent imidazole dyes 5a-d, with a suitable auxiliary donor such as aromatic rings and −OCH3 group on one end of the imidazolyl moiety and electron acceptors such as -NO2 and −COOH on other end of the compounds was achieved to get a promising fluorescent dyes for antimicrobial. The optoelectronic properties and antimicrobial studies of the synthesized materials indicated their exploration as a promising candidate as antimicrobial agents.
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Research context

OpenAlex topics: Organic Light-Emitting Diodes Research · Click Chemistry and Applications · Synthesis and Biological Evaluation

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