Mg Alloys Reduce Gastric Cancer and Mediate Therapeutic Management of Antibacterial Function

Background: Gastric cancer (GC) represents a significant challenge in global public health, and novel treatment strategies are urgently needed. This study investigated the potential application of Mg alloys for the treatment of GC through preclinical experimentation. Methods: Alloy materials were screened and selected in GC cells using cell viability assays. To uncover the mechanisms by which Mg alloys influence GC, RNA sequencing and qRT-PCR were performed. Mice bearing tumors derived from GC cells were used to assess the potential application of Mg alloys in GC. The antibacterial effects of Mg alloys were evaluated in Escherichia coli and Staphylococcus aureus. Results: Co-cultures of Mg alloys with MGC-803 cells resulted in inhibition of cell viability. RNA sequencing revealed differential mRNA expression and we validated the gene expression changes. Moreover, Mg alloy wire implantation effectively displayed that the inhibition rate of relative tumor volume reached 42.86% in tumor-bearing mice. Additionally, Mg alloys inhibited bacterial growth of two types of pathogenic bacteria, with an antibacterial rate of approximately 70%. Conclusions: Our results indicate that Mg alloys represent a novel therapeutic resource for clinical applications against GC.