journal article·2025-11-29Open access

Biomimetic Glycosaminoglycan-Enriched Electrospun Polymeric Scaffolds for Enhanced Early Tissue Regeneration

Morgane Meyer, Rana Smaida, Henri Favreau, Cristina Yus, Hervé Gegout, Manuel Arruebo, Nadia Bahlouli, Guy Ladam, Guillaume Conzatti, Stephan Lemmens, Guoqiang Hua, Florence Fioretti, Nadia Benkirane-Jessel

Journal of Functional Biomaterials· Volume 16· Issue 12

Abstract

Implantable scaffolds are increasingly recognized as transformative tools in regenerative medicine, offering the potential to prevent or mitigate tissue degeneration. Osteoarthritis is a widespread degenerative joint disease that often progresses from early focal lesions to severe joint damage, creating substantial clinical and socioeconomic burdens. Preventive strategies for early-stage lesions remain limited. This study reports the design and development of a functional polymeric scaffold intended to support early tissue regeneration and potentially prevent lesion progression. The scaffold consists of an electrospun poly (ε-caprolactone) nanofibrous membrane enriched with glycosaminoglycans, including hyaluronic acid and chondroitin sulfate, to mimic essential features of the cartilage extracellular matrix and provide a supportive microenvironment. Complete structural, physicochemical, and mechanical characterization was performed to assess the scaffold architecture, stability, hydration properties, and suitability for tissue environments. In vitro investigations were conducted to evaluate cytocompatibility and the interaction of the scaffold with relevant cell types. The scaffold is designed as a potential future preventive strategy to support cartilage integrity and limit disease progression. This approach represents a promising strategy to preserve joint integrity and function, addressing a critical unmet clinical need and enabling translation toward clinical application.
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Research context

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1260, Nanomédicine Régénérative, 1 Rue Eugène Boeckel, 67000 Strasbourg, France

Université de Strasbourg, Faculté de Chirurgie Dentaire, Faculté de Médecine, Faculté de Pharmacie, 4 Rue Blaise Pascal, 67000 Strasbourg, France

Lamina Therapeutics, 1 Rue Eugène Boeckel, 67000 Strasbourg, France

Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain

Department of Chemical Engineering, University of Zaragoza, Campus Río Ebro-Edificio I+D, C/ Poeta Mariano Esquillor S/N, 50018 Zaragoza, Spain

PBS (UMR 6270), CNRS, INSA Rouen, UNIROUEN, Normandy University, 55 rue Saint-Germain, 27000 Évreux, France

Funding

Agence Nationale de la Recherche · PhD of M.M.

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