Comparative Evaluation of the Bone Regenerative Potential of a Novel Calcium Silicate-Modified Calcium Carbonate Graft Material: Histological and Micro-Computed Tomography Assessment Using a Rat Calvarial Defect Model
Source abstract
Abstract
In the present study, we evaluated the usefulness of a porous sintered calcium carbonate body with CaSiO3 by comparing its osteogenic capacity with that of calcium carbonate without CaSiO3 and that of β-tricalcium phosphate (TP). A cranial defect model of eight-week-old male Wistar rats was divided into three groups: calcium carbonate (CC), calcium carbonate-CaSiO3 composite (CC+CS), and TP. Micro-computed tomography (CT) and histological analysis were performed at four and eight weeks postoperatively. Upon quantitative evaluation of newly formed bone volume by radiography, the CC+CS group demonstrated the highest value at eight weeks postoperatively and exhibited significantly more new bone formations than the CC group (p < 0.05). Upon histological evaluation, the CC+CS group demonstrated significantly higher new bone formation than the CC group (p < 0.05). Furthermore, in terms of residual graft material ratio, at eight weeks postoperatively, the amount of residual graft material in the CC+CS group was significantly higher than that in the TP group (p < 0.05). Therefore, the addition of CaSiO3 enhances the functional regulation of calcium carbonate-based artificial bone and can be incorporated in bone graft materials.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Implant Dentistry, Showa Medical University Graduate School of Dentistry, 2-1-1, Kita-senzoku, Ota-ku, Tokyo 145-8515, Japan
Department of Biomaterials and Engineering, Showa Medical University Graduate School of Dentistry, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
Department of Dental Education, Showa Medical University Graduate School of Dentistry, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
Tsurumi University Dental Hospital, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama-shi, Kanagawa 230-8501, Japan
Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa City, Yamagata 992-8510, Japan
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