Study on fabrication of bioabsorbable reservoir control-released drug carrier

Concerning the resolution of drawbacks existing in traditional drug administration,fabrication of bioresorbable control-released drug carrier was investigated.Firstly hydroxyapatite/collagen bone-like biomimetic composite was synthesized through self-organization mechanism of materials stimulating in vitro biomineralization process of nature bone,which was further synthesized with polylactide and the 3D porous reservoir control-released drug carrier was fabricated by thermal-induced phase separation techniques/non-solvent extraction pore leaching technology.Characterization of the specimens and release test of model compound indicated similarities of hydroxyapatite/collagen composite to nature bone and availability for control release of hydroxyapatite/collagen/polylactite drug carrier respectively.