Latest research progress of drug stability and release of PLGA microspheres

Poly(lactide-co-glycolide,PLGA) is a kind of degradable synthetic polymer which has been intensively studied as the matrix of controlled release systems.The good prospect is mainly based on its good biocompatibility,controlled biodegradability and the fact that it has been accepted for clinical applications by US/EU FDA.The microsphere controlled release systems are able to extend drug's half-life and enhance therapeutic efficacy,so they are preferentially selected in drug delivery and biomaterial domains.The stability and release dynamic of drugs are two Key issues that decide the therapeutic efficacy.This review focuses on the recent studies about the drug stability and drug release dynamic,associating our researches about the PLGA microsphere loaded with rhBMP-2 and the rhBMP-2 derived peptides.The available PLGA controlled release products are listed and the expected future is proposed.