Experiment study on hydroxyapatite bone cement as a slow-release carrier of bioactive factor

To investigate the validity of hydroxyapatite bone cement (HAC) as a slow-release carrier of bioactive factor. Experimental samples were divided to three groups:(1) Part drug group: the hydroxyapatite bone cement/norvancomyicn (HAC/NVCM) compound was implanted to tibiae of rabbit. (2)Total body drug group: the hydroxyapatite bone cement without NVCM were implanted to tibiae of rabbit, NVCM were injectived from the oto vein of rabbit. Then the drug concentrations were determined in blood and bone of animals at a series different time.(3) BMP group:After prepare of the HAC/rhBMP-2 compounds, witch were implanted to latissimus dorsal muscle pouches of rabbit, then dystopy induction of bone were viewed at 4 weeks. The experiment Results show that the drug concentrations of Part drug group in blood were all lower than that of Total body drug group at every time. But the drug concentration of Part drug group in bone were marked higher than that of Total body drug group, even at 2 weeks,the drug concentration had still 3.96μg/mg. On the surface of the HAC/rhBMP-2 compounds, the new build bone could be observed. As a slow-release carrier of drug and BMP, HAC throw out a good release characteristic.