DataVXSmall MethodsPaper
journal article·2021-11

Nonplanar Helicene Benzo[4]Helicenium for the Precise Treatment of Renal cell Carcinoma

Xiaozhen He, Fuwei Gan, Yan Zhou, Yuanliang Zhang, Peipei Zhao, Bingru Zhao, Qianyun Tang, Li Ye, Jun Bu, Junyang Mei, Ling Du, Huili Dai, Huibin Qiu, Peifeng Liu

Small Methods· Volume 5· Issue 11
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Source abstract

Abstract

Abstract Immune and targeted therapy are becoming the first‐line treatment for renal cell carcinoma (RCC). However, therapeutic outcomes are limited due to the low efficiency and side effect. Here, it is found that helicenes are able to exhibit an anticancer capability through changing the molecular structure from planar to nonplanar. Furthermore, the cytotoxicity in vitro and cancer inhibition ability of nonplanar helicenes increase with its aromatic rings’ number. It is further demonstrated that benzo[4]helicenium shows the specific killing efficiency against the RCC cancer as compared to normal kidney cells. This is majorly originated from a more selective damage of benzo[4]helicenium for mitochondria and DNA in RCC cancer cells, not the normal kidney. The selective killing ability of benzo[4]helicenium makes it have potential to be used as a targeted drug for the precise treatment of RCC.
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Research context

OpenAlex topics: DNA and Nucleic Acid Chemistry · Synthesis and Properties of Aromatic Compounds · Genetics and Neurodevelopmental Disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200032 China

Central Laboratory Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China

State Key Laboratory of Medical Genomics Shanghai Institute of Hematology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China

Funding

National Natural Science Foundation of China · Shanghai Jiao Tong University · Science and Technology Commission of Shanghai Municipality

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