DataVXSmall MethodsPaper
journal article·2021-11

Nonplanar Helicene Benzo[4]Helicenium for the Precise Treatment of Renal cell Carcinoma (Small Methods 11/2021)

Xiaozhen He, Fuwei Gan, Yan Zhou, Yuanliang Zhang, Peipei Zhao, Bingru Zhao, Qianyun Tang, Li Ye, Jun Bu, Junyang Mei, Ling Du, Huili Dai, Huibin Qiu, Peifeng Liu

Small Methods· Volume 5· Issue 11
Publisher page
Source abstract

Abstract

Front Cover In article number 2100770, Dai, Qiu, Liu and co-workers demonstrate the water-soluble benzo[4]helicenium has selective killing effects of renal cell carcinoma through inducing DNA damage. Compared with normal cells, it can more easily enter the tumor cells and further affect the biological functions of DNA because of the rapid mitosis. Benzo[4]helicenium is expected to be a novel drug for the precise therapy of renal cell carcinoma.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: DNA and Nucleic Acid Chemistry

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Affiliations

State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200032 China

Central Laboratory Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China

State Key Laboratory of Medical Genomics Shanghai Institute of Hematology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China

References

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