The Effect of Mechanical Loading on Sprouting Angiogenesis from Engineered Macro‐vessel Model (Small Methods 4/2026)
Source abstract
Abstract
Front Cover In article number 2500850, Levenberg and co-workers developed a novel stretchable macro-vessel model embedded in collagen, subjected to distinct mechanical loading profiles to study sprouting angiogenesis. Finite-element-analysis maps strain distributions, revealing that lateral stretch enhances sprouting and alignment, while longitudinal stretch inhibits it. The study offers a predictive, controllable platform to guide vascular architecture using external mechanical cues.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Angiogenesis and VEGF in Cancer · Electrospun Nanofibers in Biomedical Applications · Lipid metabolism and disorders
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Faculty of Biomedical Engineering Technion‐Israel Institute of Technology Haifa 3200003 Israel
Biological Design Center Boston University Boston MA 02215 USA
Department of Biomedical Engineering Boston University Boston MA 02215 USA
Wyss Institute for Biologically Inspired Engineering Harvard University Boston MA 02215 USA
References
Reference metadata was not supplied for this record.