DataVXSmall MethodsPaper
journal article·2018-11Open access

Liquid Biospy: Noninvasive Diagnosis and Molecular Phenotyping of Breast Cancer through Microbead‐Assisted Flow Cytometry Detection of Tumor‐Derived Extracellular Vesicles (Small Methods 11/2018)

Wenzhe Li, Bin Shao, Changliang Liu, Huayi Wang, Wangshu Zheng, Weiyao Kong, Xiaoran Liu, Guobin Xu, Chen Wang, Huiping Li, Ling Zhu, Yanlian Yang

Small Methods· Volume 2· Issue 11
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Source abstract

Abstract

Extracellular vesicle-based diagnosis and molecular phenotyping provide great help for precise diagnosis and treatment of cancer. In article 1800122, Huiping Li, Ling Zhu, Yanlian Yang, and co-workers establish an assessment for the detection and molecular phenotyping of serum extracellular vesicles using microbead-assisted flow cytometry. Molecular phenotyping is facilitated by immunostaining of important biomarkers for diagnosis, prognosis, and therapeutic evaluation on nanosized extracellular vesicles that are enriched on microsized aldehyde latex beads. This method shows great efficacy in diagnosing breast cancer and holds great potential as a surrogate for the invasive tissue-based molecular phenotyping.
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Research context

Nanomaterials

OpenAlex topics: Extracellular vesicles in disease

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Affiliations

CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China

Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing 100142 China

Clinical Laboratory Peking University Cancer Hospital & Institute Beijing 100142 China

References

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